Analysis of LTBP-1L protein role in carcinoma cell and application as cancer molecular marker

• Project/Area Number: 20790421
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: Kanazawa University
• Principal Investigator: HIGASHI Tomomi Kanazawa University, 医学系, 助教 (20293342)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 癌 / LTBP-1 / TGF-β1 / 一塩基多型 / 分子マーカー / LTBP-1L / SNP / TGF-b1 / 発現解析 / 予後解析

Research Abstract

Latent transforming growth factor (TGF)-β binding protein-1 (LTBP-1) play important roles in the secretion and activation of TGF-β. In this study, to clarify the role of LTBP-1L protein in carcinoma cell, we performed in vitro functional analysis and clinical data analysis. Our results indicate that the LTBP-1L protein can contribute to tumor initiation and progression through the induction of cell growth activity. And we indicated the possibility of the LTBP-1L protein as cancer molecular marker.

Research Products

• [Journal Article] Preconditioning with subneurotoxic allyl nitrile: protection against allyl nitrile neurotoxicity. (2010)
  • Author(s): Tanii H, Higashi T, Saijoh K
  • Journal Title: Food and Chemical Toxicology 48(2) Pages: 750-4
  • Peer Reviewed
• [Journal Article] Phylogenetic analysis of atmospheric halotolerant bacterial communities at high altitude in an Asian dust (KOSA) arrival region, Suzu City. (2010)
  • Author(s): T.Maki, S.Susuki, F.Kobayashi, M.Kakikawa, Y.Tobo, M.Yamada, T.Higashi, A.Matsuki, C.Hong, H.Hasegawa, Y.Iwasaka
  • Journal Title: Science of the Total Environment (in press)
  • Peer Reviewed
• [Journal Article] Preconditioning with subneurotoxic allyl nitrile : protection against allyl nitrile neurotoxicity. (2010)
  • Author(s): Tanii H, Higashi T, Saijoh K
  • Journal Title: Food and Chemical Toxicology 48 Pages: 750-754
  • Peer Reviewed
• [Journal Article] Purpurin is a key molecule for cell differentiation during the early development of zebrafish retina. (2009)
  • Author(s): Nagashima M, Mawatari K, Tanaka M, Higashi T, Saito H, Muramoto K, Matsukawa T, Koriyama Y, Sugitani K, Kato S
  • Journal Title: Brain Research 1302 Pages: 54-63
  • Peer Reviewed
• [Journal Article] Purpurin is a key molecule for cell differentiation during the earlydevelopment of zebrafish retina. (2009)
  • Author(s): Nagashima M, Mawatari K, Tanaka M, Higashi T, Saito H, Muramoto K, Matsukawa T, Koriyama Y, Sugitani K, Kato S
  • Journal Title: Brain Research. 1302 Pages: 54-63
  • Peer Reviewed
• [Journal Article] Dustborne Microorganisms in the atmosphere over Asian dust source region, Dunhuang. (2008)
  • Author(s): Kakikawa M, Kobayashi F, Maki T, Yamada M, Higashi T, Chen B, Shi G, Hong C, Tobo Y, Iwasaka Y
  • Journal Title: Air Quality Atmosphere and Health 1 Pages: 195-202
  • NAID: 120001088429
  • Peer Reviewed
• [Journal Article] Ecophysiological analysis of halobacteria in bioaerosol. (2008)
  • Author(s): Maki T, Susuki S, Kobayashi F, Kakikawa M, Yamada M, Higashi T, Chen B, Tobo Y, Hasegawa H, Ueda K, Iwasaka Y
  • Journal Title: Journal of Ecotechnology Research 13(4) Pages: 309-313
  • NAID: 130004956033
  • Peer Reviewed
• [Journal Article] Effect of iron stress on gene expression in harmful microalga Prymnesium parvum. (2008)
  • Author(s): Maki T, Takashi Suzuki T, Kido K, Nakahara A, Higashi T, Hasegawa H, Ueda K, Saijoh K
  • Journal Title: Journal of Ecotechnology Research 14(1) Pages: 13-16
  • NAID: 130004548672
  • Peer Reviewed
• [Journal Article] Effects of cruciferous allyl nitrile on phase 2 antioxidant and detoxification enzymes. (2008)
  • Author(s): Tanii H, Higashi H, Nishimura F, Higuchi Y, Saijoh K
  • Journal Title: Medical Science Monitor 14(10)
  • Peer Reviewed
• [Journal Article] Phylogenetic diversity and vertical distribution of a halobacterial community in the atmosphere of an Asian dust (KOSA) source region, Dunhuang City. (2008)
  • Author(s): Maki T, Susuki S, Kobayashi F, Kakikawa M, Yamada M, Higashi T, Chen B, Shi G, Hong C, Tobo Y, Hasegawa H, Ueda K, Iwasaka Y
  • Journal Title: Air Quality Atmosphere and Health 1 Pages: 81-89
  • Peer Reviewed
• [Journal Article] Effects of crucuferous allyl nitrile on phase 2 antioxidant and detoxificati on enzymes (2008)
  • Author(s): Tanii, H, Higashi T, et.al.
  • Journal Title: Medical science monitor : international medical journal of experimental and clinical research 14 Pages: 189-192
  • Peer Reviewed
• [Journal Article] Phylogenetic analysis of atmospheric halotolerant bacterial communities at high altitude in an Asian dust (KOSA) arrival region
  • Author(s): T. Maki, S. Susuki, F. Kobayashi, M. Kakikawa, Y. Tobo, M. Yamada, T. Higashi, A. Matsuki, C. Hong, H. Hasegawa, Y. Iwasaka
  • Journal Title: Science of the Total Environment (in press)
  • Peer Reviewed
• [Presentation] GSK3βによる膵がん細胞の増殖と浸潤の制御 (2009)
  • Author(s): 北野綾子, 島崎猛夫, 東朋美, 近野祐里, 石垣靖人, 元雄良治, 宮本謙一, 川上和之, 源利成
  • Organizer: 第20回日本消化器癌発生学会総会
  • Place of Presentation: 広島オリエンタルホテル(広島県)
  • Year and Date: 2009-11-27
• [Presentation] GSK3βによる膵がん細胞の増殖と浸潤の制御 (2009)
  • Author(s): 北野綾子, 島崎猛夫, 東朋美, 近野祐里, 石垣靖人, 元雄良治, 宮本謙一, 川上和之, 源利成
  • Organizer: 第20回 日本消化器癌発生学会総会
  • Place of Presentation: 広島オリエンタルホテル(広島県)
  • Year and Date: 2009-11-27
• [Presentation] Preconditioning with cruciferous allyl nitrile protects against neurotoxicity of its own. (2009)
  • Author(s): Tanii H., Higashi T., Saijoh K.
  • Organizer: 22nd Biennial Joint Meeting of the Int. Soc. for Neurochemistry and the Asian Pacific Soc. for Neurochemistry; Busan
  • Place of Presentation: BEXCO Convention Hall, Korea
• [Presentation] Preconditioning with cruciferous allyl nitrile protects against neurotoxicity of its own. (2009)
  • Author(s): Tanii H., Higashi T., Saijoh K.
  • Organizer: 22nd Biennial Joint Meeting of the Int. Soc. for Neurochemistry and the Asian Pacific Soc. for Neurochemistry
  • Place of Presentation: Busan BEXCO Convention Hall (Korea)
• [Presentation] Direct sampling and identification of bioaerosols in the convective mixed layer over KOSA region, Dunhuang, using the separate culture. (2008)
  • Author(s): Shi G, Kobayashi F, Toda S, Yamada M, Kakikawa M, Maki T, Higashi T, Hong C, Tobo Y, Chen B, Naganuma T, Iwasaka Y
  • Organizer: Proc of 5th International Workshop on Sand/ Duststorms and Associate Dustfall
  • Place of Presentation: Urumqi, Xinjiang, China
• [Presentation] Halotolerant bacterial community survived in atmosphere of Asian dust (KOSA) source region, Dunhuang City. (2008)
  • Author(s): Maki T, Susuki S, Kobayashi F, Kakikawa M, Yamada M, Higashi T, Hong C, Tobo Y, Hasegawa H, Ueda K, Iwasaka Y
  • Organizer: Proc of 5th International Workshop on Sand/ Duststorms and Associate Dustfall
  • Place of Presentation: Urumqi, Xinjiang, China
• [Presentation] Dustborne microorganisms in KOSA source region, Dunhuang. (2008)
  • Author(s): Kakikawa M, Kobayashi F, Maki T, Yamada M, Higashi T, Chen B, Shi G, Hong C, Tobo Y, Iwasaka Y
  • Organizer: Proc of 5th International Workshop on Sand/ Duststorms and Associate Dustfall
  • Place of Presentation: Urumqi, Xinjiang, China