| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We confirmed the significant association of PTPN11 G/A polymorphism at intron 3 with the risk of H.pylori-induced gastric atrophy in Japanese, revealed that TLR4+3725 G/C polymorphism, a recently-found polymorphism of TLR4, was associated with the risk of H. pylori-induced severe gastric atrophy in Japanese, and also found the novel association of RUNX3 T/A polymorphism at intron 3 with the risk of H. pylori-induced gastric atrophy in Japanese. We feel convinced that we could provide useful evidence for the prevention of gastric atrophy as a precursor of gastric cancer in Japanese.
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