Investigation of genetic risk factors for cardiovascular disease in general population.
| Project/Area Number |
20790424
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TAKASHIMA Naoyuki Shiga University of Medical Science, 生活習慣病予防センター, 特任助教 (80435883)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 循環器・高血圧 / 分子疫学 / 社会医学 / 循環器疾患 |
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| Research Abstract |
In the present investigation, we examined the association between genetic factor and risk factors of cardiovascular diseases. Single nucleotide polymorphism (SNP) rs1205 on a CRP gene was reported to be associated with serum hsCRP levels. In this study, we examined a possible association between SNP rs1205 and brachial-ankle pulse wave velocity (baPWV) as a surrogate marker for atherosclerosis, in a Japanese general population. Compared with TT genotype, CC and CT genotype was related to increased hsCRP levels (p=0.004) and decreased baPWV levels (p=0.03), although increased hsCRP levels were associated with increased baPWV levels. Further studies are needed to determine whether C allele of rs1205 on CRP predict are associated with decreased risk of atherogenic vascular change and CVD events.
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Report
(3 results)
Research Products
(2 results)
