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Antiviral activity of propolis

Research Project

Project/Area Number 20790430
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionKyushu University of Health and Welfare

Principal Investigator

SHIMIZU Tomomi  Kyushu University of Health and Welfare, 薬学部, 助教 (80412831)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords食品衛生 / プロポリス / ウイルス感染症 / 代替医療 / 健康食品 / ウィルス感染症
Research Abstract

Propolis has been worldwide as a folk medicine since ca.300 BC. It is currently used as an alternative medicine in various countries. However, in Japan, it uses as only a dietary supplement to maintain or improve human health. Because of propolis is little studied for their effects. In this study, it was examined antiviral effect and its mechanism of propolis. These results were revealed the widely usefulness and application of propolis

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 6 results) Presentation (9 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Antiviral activities of diarylheptanoids against influenza virus in vitro.2010

    • Author(s)
      Sawamura R., Sun Y., Yasukawa K., Shimizu T., Watanabe W., Kurakawa M.
    • Journal Title

      Natural Resource Letter 64

      Pages: 117-120

    • NAID

      10027709288

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of tetrabromobisphenol A, a brominated flame retardant, on the immune response to respiratory syncytial virus infection in mice.2010

    • Author(s)
      Watanabe W., Shimizu T., Sawamura R., Hino A., Konno K., Hirose A., Kurakawa M.
    • Journal Title

      International Immunopharmacology 10

      Pages: 393-397

    • Related Report
      2009 Final Research Report
  • [Journal Article] Functional disorder of primary immunity responding to respiratory syncytial virus infection in offspring mice exposed to a flame retardant, decabrominated diphenyl ether, perinatally.2010

    • Author(s)
      Watanabe W., Shimizu T., Sawamura R., Hino A., Konno K., Kurokawa M.
    • Journal Title

      Journal of Medical Virology 9999

      Pages: 1-8

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of tetrabromobisphenol A, a brominated flame retardant, on the immune response to respiratory syncytial virus infection in mice2010

    • Author(s)
      Watanabe W., Shimizu T et al.
    • Journal Title

      International Immunopharmacology 10

      Pages: 393-397

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin 12 is a primary cytokine responding to influenza virus infection in the respiratory tract of mice.2009

    • Author(s)
      Hama Y., Kurokawa M., Imakita M., Yoshida Y., Shimizu T., Watanabe W., Shiraki K.
    • Journal Title

      Acta Virologica 53

      Pages: 233-240

    • Related Report
      2009 Final Research Report
  • [Journal Article] Modulation of cytokine production by 7-hydroxycumarin in vitro and its efficacy against influenza infection in mice.2009

    • Author(s)
      Kurokawa M., Watanabe W., Shimizu T., Sawamura R., Shiraki K.
    • Journal Title

      Antiviral Research 85

      Pages: 373-380

    • Related Report
      2009 Final Research Report
  • [Journal Article] 鎮痛効果を持つピリミジンヌクレオシド誘導体2009

    • Author(s)
      木村敏行, 清水寛美, 山本郁男
    • Journal Title

      生体の科学 60(5)

      Pages: 454-455

    • Related Report
      2009 Final Research Report
  • [Journal Article] Modulation of cytokine production by 7-hydroxycumarin in vitro and its efficacy against influenza infection in mice2009

    • Author(s)
      Kurokawa M., Shimizu T., et al.
    • Journal Title

      Antiviral Research 85

      Pages: 373-380

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin 12 is a primary cytokine responding to influenza virus infection in the respiratory tract of mice2009

    • Author(s)
      Kurokawa M., Shimizu T., et al.
    • Journal Title

      Acta Virologica 53

      Pages: 233-240

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiviral activities of diarylheptanoids against influenza virus in vitro2009

    • Author(s)
      Sawamura R., Shimizu T et al.
    • Journal Title

      Natural Resource Letter 64

      Pages: 117-120

    • NAID

      10027709288

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice.2008

    • Author(s)
      Shimizu T., Hino A., Tsutsumi A., Park. Y.K., Watanabe W., Kurokawa M.
    • Journal Title

      Antiviral Chemistry & Chemotherapy 19

      Pages: 7-13

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of decabrominated diphenyl ether(DBDE) on developmental immunotoxicity in offspring mice.2008

    • Author(s)
      Watanabe W., Shimizu T., Hino A., Kurokawa M.
    • Journal Title

      Environmental Toxicology and Pharmacology 26

      Pages: 315-319

    • Related Report
      2009 Final Research Report
  • [Journal Article] Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice2008

    • Author(s)
      Shimizu T., et.al.
    • Journal Title

      Antiviral Chemistry & Chemotherapy 19

      Pages: 7-13

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of decabrominated diphenyl ether(DBDE) on developmental immunotoxicity in offspring mice2008

    • Author(s)
      Watanabe W., Shimizu T., et al.
    • Journal Title

      Environmental Toxicology and Pharmacology 26

      Pages: 315-319

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗インフルエンザウイルス活性を有するプロポリスAF-08の活性物質の探索(2)2010

    • Author(s)
      清水寛美, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山桃太郎アリーナ(岡山県)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗インフルエンザウイルス活性を有するプロポリスAF-08の活性物質の探索(2)2010

    • Author(s)
      清水寛美, 渡辺渡, 澤村理英, 日野あかね, 安川憲, 堤淳子, 堤重敏, Y.K. Park, 黒川昌彦
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗インフルエンザウイルス活性を有するプロポリスAF-08の活性物質の探索2009

    • Author(s)
      清水寛美, 他
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロポリスAF-08の抗インフルエンザウイルス活性画分の探索とその作用機序解析2009

    • Author(s)
      清水寛美, 他
    • Organizer
      日本薬学会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗インフルエンザウイルス活性を有するプロポリスAF-08の活性物質の探索2009

    • Author(s)
      清水寛美, 渡辺渡, 澤村理英, 堤淳子, 堤重敏, 安川憲, 黒川昌彦
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] プロポリスAF-08の抗インフルエンザウイルス作用機序解析とその活性画分の検討2008

    • Author(s)
      清水寛美, 他
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 臭素化難燃物暴露によるrsウイルス感染病態の増悪化に対するプロポリスの効果2008

    • Author(s)
      清水寛美, 渡辺渡, 澤村理英, 日野あかね, 堤重敏, Y.K. Park, 黒川昌彦
    • Organizer
      第18回抗ウイルス療法研究会
    • Place of Presentation
      鹿児島
    • Related Report
      2009 Final Research Report
  • [Presentation] プロポリスAF-08の抗インフルエンザウイルス作用機序解析とその活性画分の検討2008

    • Author(s)
      清水寛美, 渡辺渡, 澤村理英, 堤淳子, 堤重敏, 安川憲, 黒川昌彦
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Related Report
      2009 Final Research Report
  • [Presentation] プロポリスAF-08およびその活性画分の抗インフルエンザウイルス作用と作用機序解析2008

    • Author(s)
      清水寛美, 渡辺渡, 澤村理英, 日野あかね, 安川憲, 堤淳子, 堤重敏, Y.K. Park, 黒川昌彦
    • Organizer
      第25回日本薬学会九州支部大会
    • Place of Presentation
      宮崎
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 抗インフルエンザウイルス剤2009

    • Inventor(s)
      安川憲, 黒川昌彦, 清水寛美, 澤村理英
    • Industrial Property Rights Holder
      安川憲, 黒川昌彦, 清水寛美, 澤村理英
    • Acquisition Date
      2009-11-27
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 特許2008

    • Inventor(s)
      安川憲、清水寛美, 他
    • Industrial Property Rights Holder
      安川憲、清水寛美, 他
    • Industrial Property Number
      2008-302042
    • Filing Date
      2008-11-27
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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