| Project/Area Number |
20790432
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | National Institute for Environmental Studies |
|---|
Principal Investigator |
YANAGISAWA Rie National Institute for Environmental Studies, 環境健康研究領域, 研究員 (70391167)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 食品衛生 / アレルギー・ぜんそく / マイクロアレイ / 環境 / 免疫学 / 衛生 |
|---|
| Research Abstract |
Pesticide residues, ones of environmental pollutants, may increase the potency of allergens and thereby play a role in the onset and progression of allergic diseases. We determined whether oral exposure to pesticides in early childhood affect allergic diseases including atopic dermatitis and allergic airway inflammation in murine model. Exposure to pesticides did not show significant enhancing effects in atopic dermatitis-like skin lesions either male or female mice. On the other hand, γ- benzene hexachloride (BHC) aggravated allergen-related airway inflammation in female mice, but not male mice. Taken together, oral exposure to pesticides in early childhood can show various effects in the type of disorders and/or sex differences.
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