Diagnostic application of the NoV-histo blood group antigen interaction
| Project/Area Number |
20790433
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
SHIRATO Haruko National Institute of Infectious Diseases, ウイルス第二部, 主任研究官 (60356243)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ウイルス / 糖鎖 / ノロウイルス |
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| Research Abstract |
Since NoV forms many antigenically diverse groups, identification of the common NoV binding epitopes on host cells should be useful for the screening and diagnosis of NoV. In this study, I analyzed the recognition sites on histo blood group antigens by NoV with surface plasmon resonance assay, flow cytometry assays and x-ray crystallographic.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Noroviruses Distinguish between Type 1 and Type 2 Histo-Blood Group Antigens for Binding.2008
Author(s)
H.Shirato, S.Ogawa, H.Ito, T.Sato, A.Kameyama, H.Narimatsu, Z.Xiaofan, T.Miyamura, T.Wakita, K.Ishii, N.Takeda.
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Journal Title
Journal of Virology 82
Pages: 10756-10767
Related Report
Peer Reviewed
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