Molecular epidemiology of malignant lymphoma
| Project/Area Number |
20790434
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
KAWASE Takakazu Aichi Cancer Center Research Institute, 疫学・予防部, 主任研究員 (30463194)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 悪性リンパ腫 / 染色体異常 / API2-MALT1 キメラ遺伝子 / 胃十二指腸潰瘍 / API2-MALT1キメラ遺伝 / 飲酒習慣 / 喫煙習慣 |
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| Research Abstract |
t(11 ; 18)(q21 ; q21)の遺伝子異常によるAPI2-MALT1キメラ遺伝子陽性例と陰性例で予後の異なるMALTリンパ腫に注目し症例対症研究を施行した。その結果はAPI2-MALT1キメラ遺伝子陽性のMALTリンパ腫発症にはH.Pyloliの感染が一因と考えられている胃十二指腸潰瘍の既往との相関がない事を示唆しており、API2-MALT1キメラ遺伝子陽性のMALTリンパ腫と陰性のMALTリンパ腫で病因が異なることが考えられた。
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism.2009
Author(s)
Takakazu Kawase, Keitaro Matsuo, Koichi Kashiwase, Hidetoshi Inoko, Hiroh Saji, Seishi Ogawa, Shunichi Kato, Takehiko Sasazuki, Yoshihisa Kodera, Yasuo Morishima, Yasuo Morishima
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Journal Title
Blood 113(12)
Pages: 2851-8
Related Report
Peer Reviewed
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