High level of plasma ET-1 predicts the development of hypertension after seven years
| Project/Area Number |
20790452
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Public health/Health science
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| Research Institution | Kurume University |
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Principal Investigator |
KUMAGAE Shun-ichi Kurume University, 医学部, 助教 (20412504)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | エンドセリン / 高血圧症 / コホート研究 / 動脈硬化 / 解析・評価 |
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| Research Abstract |
Endothelin-1 (ET-1) is a potent vasoconstrictor derived from the endothelium. The present study was designed to determine whether high plasma ET-1 levels predict the development of hypertension. 1,492 subjects received a health examination in 1999. Eight years later, 1,261 subjects were re-examined. Of 814 normotensives at baseline, 222 subjects developed hypertension. We divided the baseline plasma ET-1 levels into quartiles. The odds ratio for the development of hypertension after 8 years was 1.79 (95% CI, 1.08-2.96) in the highest quartile vs. the lowest quartile of ET-1 level after adjustment for confounding factors.
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Report
(3 results)
Research Products
(3 results)
