Identification of genetic markers for rhabdomyolysis indused by drug and the establishment of gene diagnosis

• Project/Area Number: 20790468
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Legal medicine
• Research Institution: Fukuoka University
• Principal Investigator: MATSUSUE Aya Fukuoka University, 医学部, 助教 (70309920)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 法医学 / 横紋筋融解症 / 薬毒物 / 遺伝子変異

Research Abstract

There is a possibility that rhabdomyolysis related to drug can be caused by genetic background. We analyzed potential rhabdomyolysis-susceptibility genes in autopsy cases of drug poisoning such as methamphetamine. But there was no obvious relationship between the genetic mutations observed in this study and rhabdomyolysis. A lot more autopsy cases of rhabdomyolysis were required and investigation of other rhabdomyolysis-susceptibility genes helps to clear association between rhabdomyolysis and genetic background.

Research Products

• [Journal Article] An autopsy case of rhabdomyolysis related to vegetamin and genetic analysis of the rhabdomyolysis-associated genes. (2010)
  • Author(s): Matsusue A, Hara K, Kageura M, Kashiwagi M, Wang L, Ishigami A, Gotohda T, Tokunaga I, Nisimura A, Sugimura T, Kubo S.
  • Journal Title: J Forensic Leg Med. 17(1) Pages: 46-9
  • Peer Reviewed
• [Journal Article] An autopsy ease of rhabdomyolysis related to vegetamin and genetic analysis of the rhabdomyolysis-associated genes (2010)
  • Author(s): Matsusue A
  • Journal Title: Journal of Forensic and Legal Medicine 17(1) Pages: 46-49
  • Peer Reviewed
• [Journal Article] Genetic analysis of ryanodine receptor l gene and carnitine palmitoyltransferase II gene: An autopsy case of neuroleptic malignant syndrome related to vegetamin. (2009)
  • Author(s): Matsusue A, Hara K, Kageura M, Kashiwagi M, Wang L, Ishigami A, Gotohda T, Tokunaga I, Nisimura A, Sugimura T, Kubo S.
  • Journal Title: Leg Med. 11
  • Peer Reviewed
• [Journal Article] Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene : An autopsy case of neuroleptic malignant syndrome related to vegetamin (2009)
  • Author(s): Matsusue A
  • Journal Title: Legal Medicine 11
  • NAID: 10027263878
  • Peer Reviewed
• [Presentation] Genetic analysis of ryanodine receptor l gene and carnitine palmitoyltransferase II gene: An autopsy case of neuroleptic malignant syndrome related to vegetamin. (2009)
  • Author(s): Matsusue A, Hara K, Kageura M, Kashiwagi M, Wang L, Ishigami A, Gotohda T, Tokunaga I, Sugimura T, Kubo S.
  • Organizer: 7th International Symposium on Advances in Legal Medicine
  • Place of Presentation: Lisbon
  • Year and Date: 2009-05-28
• [Presentation] Genetic analysis of rhabdomyolysis-associated genes : an autopsycase of methamphetamine-related hyperthermia and acidosis (2009)
  • Author(s): Matsusue A
  • Organizer: 21st Congress of the International Academy of Legal Medicine
  • Place of Presentation: Lisbon(Portugal)
  • Year and Date: 2009-05-28
• [Presentation] 横紋筋融解症における遺伝学的背景の検討:ベゲタミン中毒の一剖検例(第3報) (2008)
  • Author(s): 松末綾, 原健二, 影浦光義, 柏木正之, 杉村朋子, 久保真一
  • Organizer: 第58回日本法医学会九州地方会
  • Place of Presentation: 大分
  • Year and Date: 2008-10-25
• [Presentation] 横紋筋融解症における遺伝学的背景の検討 : ベゲタミン中毒の1剖検例(第3報) (2008)
  • Author(s): 松末綾
  • Organizer: 第58回日本法医学会九州地方会
  • Place of Presentation: 大分
  • Year and Date: 2008-10-25
• [Presentation] Genetic analysis of rhabdomyolysis-associated genes: an autopsy case of methamphetamine-related hyperthermia and acidosis. (2008)
  • Author(s): Matsusue A., Ishigami A., Hara K., Kashiwagi M., Kageura M., Sugimura T., Kubo S.
  • Organizer: 21st Congress of the International Academy of Legal Medicine
  • Place of Presentation: Osaka
  • Year and Date: 2008-09-05
• [Presentation] Genetic analysis of ryanodine receptorl gene and carnitine palmitoyl transferase II gene : An autopsy case of neuroleptic malignant syndrome related to vegetamin (2008)
  • Author(s): 松末綾
  • Organizer: The 7th International Symposium ADVANCES INLEGAL MEDICINE
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-05
• [Presentation] 横紋筋融解症におけるRYR1遺伝子変異の検討:ベゲタミン中毒の1剖検例 (2008)
  • Author(s): 松末綾, 原健二, 影浦光義, 柏木正之, LuWang, 石上安希子, 後藤田貴子, 徳永逸夫, 柏村征一, 久保真一
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-24
• [Presentation] 横紋筋融解症におけるRYR1遺伝子変異の検討 : ベゲタミン中毒の1剖検例 (2008)
  • Author(s): 松末綾
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-24