Relationship between the adverse effect of kampo medicine and transporters

• Project/Area Number: 20790475
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Nagoya City University
• Principal Investigator: MAKINO Toshiaki Nagoya City University, 大学院・薬学研究科, 准教授 (80326561)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 東洋医学 / 甘草 / 偽アルドステロン症 / 有機アニオントランスポーター / グリチルリチン酸 / ヒドロキンステロイド脱水素酵素 / グリチルレチン酸 / 漢方薬 / 副作用 / ヒドロキシステロイド脱水素酵素

Research Abstract

Glycyrrhizae Radix has the adverse effect to cause pseudoaldosteronism. It is considered that pseudoaldosteronism is induced by glycyrrhitinic acid (GA) that inhibits 11β-hydroxysteroid dehydrogenase II in renal tubular epithelial cells. The present study reveals that GA cannot pass through the membrane of epithelial cells, but 3-monoglucuronyl glycyrrhietinic acid (3MGA) can actively be transported through the membrane by orgaic anion transporters. It is suggested that the adverse effect of licorice would be occurred not by GA but 3MGA.

Research Products

• [Journal Article] Down-regulation of a hepatic transporter Mrp2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury. (2008)
  • Author(s): Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue, Hajime Mizukami.
  • Journal Title: Drug Metab. Dispos. 36(7) Pages: 1438-1443
  • Peer Reviewed
• [Journal Article] Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury (2008)
  • Author(s): Makino T, Ohtake N, Watanabe A, Tsuchiya N, Imamura S, Iizuka S, Inoue M, Mizukami H
  • Journal Title: Drug Metab Dispos 7 Pages: 1438-1443
  • Peer Reviewed
• [Presentation] グリチルリチンおよびその代謝物の腎における11β-HSD II阻害作用の比較 (2010)
  • Author(s): 上林理絵、牧野利明、井上勝央、水上元、大嶽信弘
  • Organizer: 第130回日本薬学会年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-29
• [Presentation] グリチルリチンおよびその代謝物の腎における11 β-HSD II阻害作用の比較 (2009)
  • Author(s): 上林理絵、牧野利明、井上勝央、水上元、大嶽信弘
  • Organizer: 第130回日本薬学会年会
  • Place of Presentation: 岡山