Identification of a biomarker for the chronic fatigue syndrome

• Project/Area Number: 20790476
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Osaka City University
• Principal Investigator: IKEJIMA Nobue Osaka City University, 大学院・医学研究科, 博士研究員 (50420401)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ストレス科学 / 疲労 / 下垂体ホルモン / 分子生物学 / 免疫

Research Abstract

Biological markers for chronic fatigue syndrome (CFS) have long been sought. In animal model for chronic stress, hyper-activation of melanotroph in pituitary gland and the increase of alpha-melanocyte stimulating hormone (α-MSH) level in plasma were demonstrated. In this regard an increase of α-MSH level in plasma of CFS patients who suffer from prolonged stress may be expected. We therefore examined α-MSH levels in CFS patients. CFS patients who suffer less than 5 years had significantly higher levels of α-MSH in their peripheral blood. The α-MSH could be a potent biological marker to diagnose CFS at least during the first 5 years from the onset.

Research Products

• [Journal Article] Chronic stress elicits prolonged activation of alpha-MSH secretion and subsequent degeneration of melanotroph (2009)
  • Author(s): Ogawa T, Shishioh-Ikejima N, Konishi H, Makino T, Sei H, Kiryu-Seo S, Tanaka M, Watanabe Y, Kiyama H.
  • Journal Title: J Neurochem 109(5) Pages: 1389-99
  • Peer Reviewed
• [Journal Article] Chronic stress elicits prolonged activation of α-MSH secrestion and subsequent degeneration of melanotropha (2009)
  • Author(s): Tokiko Ogawa
  • Journal Title: Journal of Neurochemistry (In press)
  • Peer Reviewed
• [Journal Article] 疲労ラット下垂体細胞の過労死とその機序
  • Author(s): 小川登紀子、池島(獅子王)信江、木山博資
  • Journal Title: 日本疲労学会誌 (in press)
• [Presentation] 下垂体細胞の過労死の表情 (2010)
  • Author(s): 小川登紀子
  • Organizer: 日本解剖学会
  • Place of Presentation: 岩手
  • Year and Date: 2010-03-28
• [Presentation] 神経損傷時における脂質輸送関連ABCトランスポーターA1の発現 (2009)
  • Author(s): 池島(獅子王)信江
  • Organizer: 第85回日本解剖学近畿支部学術集会
  • Place of Presentation: 奈良
  • Year and Date: 2009-11-28
• [Presentation] Prolonged stress affects the hypothalamic dopamine system and causes degeneration of the pituitary cells (2009)
  • Author(s): Ogawa T., Shishioh-Ikejima N., Konishi H., Makino T., Kiryu-Seo S., Tanaka M., Watanabe Y., Kiyama H.
  • Organizer: Biennial Meeting of the International Society for Neurochemistry
  • Place of Presentation: Bussan Korea
  • Year and Date: 2009-08-27
• [Presentation] Prolonged stress affects the hypothalamic dopamine system and causes degeneration of the pituitary cells. (2009)
  • Author(s): Tokiko Ogawa
  • Organizer: Biennial Meeting of the International Society for Neurochemistry
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-08-27
• [Presentation] 慢性ストレス負荷ラット下垂体中間葉においてドーパミンレベル低下により誘導されるpancreatitis-associated protein Iの発現 (2009)
  • Author(s): 小西博之
  • Organizer: 日本神経化学会大会
  • Place of Presentation: 群馬
  • Year and Date: 2009-06-23
• [Presentation] 疲労ラットにおける成長ホルモン産生細胞の機能阻害メカニズム (2009)
  • Author(s): 小川登紀子、池島(獅子王)信江、牧野哲也、小西博之、木山博資
  • Organizer: 日本疲労学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-16
• [Presentation] 慢性疲労症候群早期患者における血中α-MSHレベルの上昇 (2009)
  • Author(s): 池島(獅子王)信江、小川登紀子、山口浩二、倉恒弘彦、渡辺恭良、木山博資
  • Organizer: 日本疲労学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-15
• [Presentation] 過労モデル動物における脳内変化とその影響 (2009)
  • Author(s): 木山博資、小川登紀子、池島(獅子王)信江、牧野哲也
  • Organizer: 日本疲労学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-15
• [Presentation] 疲労モデルラットにおける炎症応答の変化 (2008)
  • Author(s): 池島(獅子王)信江、牧野哲也、小川登紀子、木山博資
  • Organizer: 日本解剖学近畿支部学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-29
• [Presentation] Expression of ABCA1 transporter is up-regulated in response to nerve injury (2008)
  • Author(s): Nobue Shishioh-Ikejima
  • Organizer: 第51回日本神経化学会(富山)大会
  • Place of Presentation: 富山市
  • Year and Date: 2008-09-12
• [Presentation] Disorders of homeostasis centers in fatigued rat (2008)
  • Author(s): Hiroshi Kiyama Nobue Shishioh-Ikejima, Tokiko Ogawa
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: 沖縄
  • Year and Date: 2008-09-04
• [Presentation] Disorders of homeostasis centers in fatigued rat (2008)
  • Author(s): Hiroshi Kiyama
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: 沖縄県名護市
  • Year and Date: 2008-09-04
• [Presentation] Alteration of inflammatory responses to LPS in rat fatigue model (2008)
  • Author(s): Nobue Shishioh-Ikejima, Tetsuya Makino, Tokiko Ogawa, Hiroshi Kiyama
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: 沖縄
• [Presentation] Prolonged fatigue exhibits the opposed proliferation regulations in the anterior and intermediate pituitary cells (2008)
  • Author(s): Tokiko Ogawa, Nobue Shishioh-Ikejima, Hiroshi Kiyama
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: 沖縄
• [Presentation] Alteration of inflammatory responses to LPS in rat fatigue model (2008)
  • Author(s): Nobue Shishioh-Ikejima
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: 沖縄県名護市
• [Presentation] Prolonged fatigue exhibits the opposed proliferation regulations in the anterior and intermediate pituitary cells (2008)
  • Author(s): Tokiko Ogawa
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: 沖縄県名護市
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/anatomy1/works/works-top.html
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/21coe/index.html
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/anatomvl/works/works-top.html
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/21coe/index.html
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/anatomyl/works/works-top.html
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/21coe/index.html
• [Patent(Industrial Property Rights)] 疲労度の判定方法および疲労判定キット (2009)
  • Inventor(s): 木山博資、池島信江、小川登紀子、渡辺恭良、倉恒弘彦
  • Industrial Property Rights Holder: 大阪市立大学
  • Industrial Property Number: 2009-115685
  • Filing Date: 2009-05-12