| Project/Area Number |
20790483
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
JUN Inoue Tohoku University, 病院, 医員 (60455821)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 肝臓学 / ウイルス性肝炎 / 肝臟学 |
|---|
| Research Abstract |
To clarify the mechanism of fulminant hepatitis induced by hepatitis B virus (HBV), we focused on a HBV strain obtained from a patient in fulminant hepatitis outbreak, and investigated the significance of mutations found in the strain and the impact to the infected cells. As a result, we demonstrated that the HBV replicative intermediates of HBV with the mutations were increase in the cells, and HBV core protein was accumulated in the nucleus of HBV-transfected cells. Moreover, the strain had direct cytotoxicity, and a part mechanism of fulminant hepatitis was clarified.
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