| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In the liver, stromal cell derived factor-1 (SDF-1) is produced in the bile duct and hepatic stem/progenitor cells. In this study, we analyzed the role of SDF-1 by using the CXCR4 conditional knock out (KO) mice (CXCR4 is the receptor of SDF-1). By analyzing the liver damaged CXCR4 KO mice, we realized that although in the liver hepatic stem/progenitor cells increased, the recovery of liver regeneration was delayed. These results reveal that the role of SDF-1/CXCR4 axis works positive effect for liver regeneration.
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