Regulation of Wnt signaling by activated innate immunity in intestinal epithelium.

Research Project

Project/Area Number	20790492
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Gastroenterology
Research Institution	Kyoto University
Principal Investigator	KOMEKADO Hideyuki Kyoto University, 医学研究科, 助教 (90452359)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	下部消化管学(小腸・大腸) / 消化管Wntシグナル / 下部消化管学 / Wntシグナル / Stat3
Research Abstract	We investigated how microenvironment regulates cell growth in gastrointestinal epithelium. IL-6 secreted by epithelial cells was shown to regulate cell growth through STAT3 activation, probably via the nuclear translocation of beta-catenin by STAT3 and resulting Wnt signaling activation. Innate immunity has been reported to regulate intestinal microenvironment, and the crosstalk between innate immunity and Wnt signaling shoud be further analyzed.

Report

(3 results)