Regulation of Wnt signaling by activated innate immunity in intestinal epithelium.
| Project/Area Number |
20790492
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
KOMEKADO Hideyuki Kyoto University, 医学研究科, 助教 (90452359)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 下部消化管学(小腸・大腸) / 消化管Wntシグナル / 下部消化管学 / Wntシグナル / Stat3 |
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| Research Abstract |
We investigated how microenvironment regulates cell growth in gastrointestinal epithelium. IL-6 secreted by epithelial cells was shown to regulate cell growth through STAT3 activation, probably via the nuclear translocation of beta-catenin by STAT3 and resulting Wnt signaling activation. Innate immunity has been reported to regulate intestinal microenvironment, and the crosstalk between innate immunity and Wnt signaling shoud be further analyzed.
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Report
(3 results)
Research Products
(1 results)
