Identification and character ization of novel transcription programs required for lipid synthesis in the liver

Research Project

Project/Area Number	20790496
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Gastroenterology
Research Institution	The University of Tokushima
Principal Investigator	HARADA Nagakatsu The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (40359914)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	脂質合成 / 遺伝子 / 転写 / マウス / 脂肪肝 / mRNAバリアント / プロモーター
Research Abstract	Glycerol-3-phosphate acyltmnsferase (GPAT) acts as a rate limiting enzyme in de novo lipid synthesis. GPAT is now a candidate for targeted treatment of the excess lipid accumulation that is associated with obesity and Non-alcoholic Fatty Liver Disease. In the present study, I clarified mechanisms of enhanced GPAT gene expression induced by feeding or obesity using cultured cells and mice.

Report

(3 results)