Cancer therapy by the adenovirus expressing p53 and miRNA
| Project/Area Number |
20790501
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
IDOGAWA Masashi Sapporo Medical University, 医学部, 助教 (00404749)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 遺伝子治療 / p53 / miRNA / p21 / アデノウイルスベクター / 癌 / アポトーシス / 治療抵抗性 |
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| Research Abstract |
We examined the therapeutic effectiveness of adenovirus (Ad-p53/miR-p21) that encoded co-cistronic p53 and artificial microRNAs (miRNAs) that targeted p21. Tumor volume was significantly decreased following the direct injection of Ad-p53/miR-p21 into the tumor, as compared to the injection of Ad-p53/miR-control. Our results suggest that adenovirus-mediated transduction of p53 and p21-specific miRNAs may be useful for gene therapy of human cancers.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] p53 family members regulate the expression of the apolipoprotein D gene.2009
Author(s)
Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
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Journal Title
Journal of Biological Chemistry 284(2)
Pages: 872-83
Related Report
Peer Reviewed
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[Journal Article] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.2009
Author(s)
Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kahima R, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T
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Journal Title
BMC Cancer 9
Pages: 198-198
Related Report
Peer Reviewed
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