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The effect of DGAT on liver steatosis, fibrosis and carcinogenesis in murine NASH models.

Research Project

Project/Area Number 20790503
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

YAMAGUCHI Kanji  Kyoto Prefectural University of Medicine, 医学研究科, 助教(寄附講座) (50381950)

Research Collaborator ITOH Yoshito  京都府立医科大学, 医学研究科, 准教授 (70244613)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsDGAT / 炎症 / 肝脂肪化 / 肝線維化 / 肝発癌
Research Abstract

Suppression of DGAT2, which is highly expressed in hepatocytes, ameliorated liver steatosis but worsened liver fibrosis. This observation suggests that triglyceride synthesis helps to protect the liver from lipotoxicity by buffering FFA accumulation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (6 results)

All 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice.2010

    • Author(s)
      Yamaguchi K, Itoh Y, Yokomizo C, Nishimura T, Niimi T, Fujii H, Okanoue T, Yoshikawa T.
    • Journal Title

      Lab Invest. 90(8)

      Pages: 1169-1178

    • Related Report
      2010 Final Research Report
  • [Journal Article] Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice.2010

    • Author(s)
      Yamaguchi Kanji, et al.
    • Journal Title

      Laboratory investigation

      Volume: Aug;90(8) Pages: 1169-78

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス脂肪肝、脂肪性肝炎モデルにおけるIL-6と肝脂肪化の関係について2009

    • Author(s)
      山口寛二、伊藤義人、横溝千尋、西村健、新美敏久、岡上武、吉川敏一
    • Organizer
      第38回日本肝臓学会西部会
    • Place of Presentation
      鳥取
    • Year and Date
      2009-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Blockade of Interleukin 6 Trans-Signaling Enhanced Hepatic Steatosis but Improved Liver Injury in Methionine Choline Deficiency Diet-Fed Mice2009

    • Author(s)
      山口寛二
    • Organizer
      第54回アメリカ肝臓学会
    • Place of Presentation
      アメリカ、ボストン
    • Year and Date
      2009-11-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inhibiting Interleukin-6/GP130 Signaling in Hepatocytes Worsens Hepatic Steatosis and Fibrosis in Lean and db/db mice Fed Methionine Choline Deficient Diets.2008

    • Author(s)
      Kanji Yamaguchi, Yoshito Itoh, Toshihisa Niimi, Norihiro Mitsuyoshi, Koichiro Yasui, Masahito Minami, Masaki Iwai, Okanoue Takeshi, Toshikazu Yoshikawa
    • Organizer
      第59回アメリカ肝臓病学会(ポスター)
    • Place of Presentation
      サンフランシスコアメリカ
    • Year and Date
      2008-11-03
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス脂肪性肝炎モデルにおけるDGAT ASOの効果について2008

    • Author(s)
      山口寛二、伊藤義人、横溝千尋、西村健、新美敏久、岡上武、吉川敏一
    • Organizer
      第44回日本肝臓学会総会ワークショップ
    • Place of Presentation
      愛媛
    • Year and Date
      2008-06-04
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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