Is monocytes from Crohn's disease patients hyper-activated by fatty acid?
| Project/Area Number |
20790504
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
TORISU Takehiro Kyushu Dental College, 歯学部, 助教 (30453228)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 下部消化管 / クローン病 / 下部消化管学 |
|---|
| Research Abstract |
Our hypothesis is "Macrophages from Crohn's disease (CD) patients are hyper-activated by fatty acid". We collected macrophages from CD patients and healthy controls. These cells were stimulated by fatty acid. And then we measured the cytokines in culture medium. These cytokines were up-regulated in macrophage from CD patients than healthy control. Because CD163 is recently used as a marker for anti-inflammatory macrophage, we measure CD163 of macrophage in CD patients. CD163 from CD patients were up-regulated than healthy controls. Soluble CD163 which can measure by ELISA also increased in plasma from CD patients. Soluble CD163 was correlated with disease activity. The conclusion of this study is as follow. Because there is difference of some modulators such as cytokines in serum between CD patients and controls, the differentiation of macrophages are also different between CD patients and controls. These inflammatory macrophages in CD patients are hyper-activated by fatty acid.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Possible association of atrophic gastritis and arterial stiffness in the healthy middle-aged Japanese2009
Author(s)
Torisu T*, Takata Y, Ansai T, Matsumoto T, Sonoki K, Soh I, Awano S, Yoshida A, Hamasaki T, Kagiyama S, Nakamichi I, Ohsumi T, Toyoshima K, Nishihara T, Iida M, Takehara T.
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Journal Title
J Atheroscler Thromb 16(5)
Pages: 691-697
NAID
Related Report
Peer Reviewed
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[Journal Article] IgA level is associated with risk for mortality in 80-year old population2009
Author(s)
Torisu T*, Takata Y, Ansai T, Soh I, Awano S, Sonoki K, Kagiyama S, Nakamichi I, Yoshida A, Hamasaki T, Matsumoto T, Iida M, Takehara T.
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Journal Title
Gerontology 55(2)
Pages: 179-185
Related Report
Peer Reviewed
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[Journal Article] Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in Japanese population2008
Author(s)
Torisu T*, Matsumoto T, Takata Y, Ansai T, Soh I, Awano S, Nakamichi I, Kagiyama S, Sonoki K, Yoshida A, Hamasaki T, Iida M, Takehara T.
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Journal Title
J Gastroenterol 43(10)
Pages: 762-6
NAID
Related Report
Peer Reviewed
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