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Effect of nitorosylated- and phosphorylated-RKIP on cell-proliferation signal in gastric cancer cells

Research Project

Project/Area Number 20790505
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionJosai University

Principal Investigator

OHTAKE Kazuo  Josai University, 薬学部, 助教 (50337482)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords癌 / 整理活性 / 蛋白質 / シグナル伝達 / 一酸化窒素 / ニトロソ化 / 細胞増殖 / 翻訳後修飾 / 生理活性 / RKIP / リン酸化 / Raf / ERK
Research Abstract

The purpose of the current study is to evaluate the effect of nitorosylated- and phosphorylated-RKIP (Raf kinase inhibitor protein) on cell-proliferation signal in human gastric cancer (AGS) cells. RKIP-nitrosylation was significant reduction in the phophorylation level of RKIP in AGS cells. On the other hand, cell proliferation signal was up-regulated by an expressive increase in nitrosylation level of RKIP.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (9 results)

All 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] Proteomic approach for identification of protein S-nitrosation in mouse gastric mucosa treated with S-nitrosoglutathione2009

    • Author(s)
      Ohtake K, Shimada N, Uchida N, Kobayashi
    • Journal Title

      J. Proteomics 72

      Pages: 750-760

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic approach for identification of protein S-nitrosation in mouse gastric mucosa2009

    • Author(s)
      Ohtake K, Shimada N, Uchida N, Kobayashi
    • Journal Title

      Nitric Oxide 20

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic approach for identification of protein S-nitrosation in mousegastric mucosa treated with S-nitrosoglutathione2009

    • Author(s)
      K.Ohtake, 他3名
    • Journal Title

      J Proteomics 72

      Pages: 750-760

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic approach for identification of protein S-nitrosation in mousegastric mucosa2009

    • Author(s)
      K.Ohtake, 他3名
    • Journal Title

      Nitric Oxide 20

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Proteomic approach for identification of protein S-nitrosation in mouse gastric mucosa2009

    • Author(s)
      K Ohtake, 他3名
    • Organizer
      THIRD INTERNATIONAL MEETING ON THE ROLE OF NITRITE IN PHYSIOLOGY, PATHOPHYSIOLOGY, AND THERAPERUTICS
    • Place of Presentation
      スウェーデンストックホルムカロリンスカ研究所
    • Year and Date
      2009-06-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Proteomic approach for identification of protein S-nitrosationin mouse gastric mucosa2009

    • Author(s)
      K Ohtake, 他3名
    • Organizer
      THIRD INTERNATIONAL MEETING ONTHE ROLE OF NITRITE IN PHYSIOLOGY, PATHOPHYSIOLOGY, AND THERAPERUTICS
    • Place of Presentation
      スウェーデン ストックホルム カロリンスカ研究所
    • Year and Date
      2009-06-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] S-ニトロソ化RKIPはRKIPリン酸化を阻害し、ERKリン酸化を活性化する2009

    • Author(s)
      大竹一男, 他3名
    • Organizer
      第9回日本NO学会学術集会
    • Place of Presentation
      静岡グランシップ
    • Year and Date
      2009-05-08
    • Related Report
      2009 Final Research Report
  • [Presentation] S-ニトロソ化RKIPはRKIPリン酸化を阻害し、 ERI(リン酸化を活性化する2009

    • Author(s)
      大竹一男, 他3名
    • Organizer
      第9回日本NO学会学術集会
    • Place of Presentation
      静岡 グランシップ
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト胃細胞におけるNOストレスはRKIP非依存的にERKをリン酸化する2009

    • Author(s)
      大竹一男
    • Organizer
      第129回日本薬学会年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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