Enhanced ghrelin production and secretion and reduced expression of ghrelin receptor in rat stomach with delayed gastric emptying

• Project/Area Number: 20790506
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: IWASAKI Eisuke Keio University, 医学部, 助教 (10366172)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: グレリン / 胃排出 / GHS受容体 / 胃運動 / 肥満 / 機能性デイスペプシア / 胃排出障害 / カハール介在細胞 / 迷走神経 / 機能性ディスペプシア

Research Abstract

Ghrelin is a gastrointestinal peptide that exerts distinct effects on the gastrointestinal motility through the vagus nerve and gastric excitatory neural plexus. We investigated the influence of gastric outlet obstruction caused by surgical manipulation on the dynamics of ghrelin, GHS receptor or the gastric neural network in rats. This study had provided the first evidence that production and secretion of gastric ghrelin was enhanced with down-regulation of GHS receptor in rats with gastric outlet obstuction. The elevation of plasma ghrelin levels in rats with gastric outlet obstruction may stimulate gastric motility through activation of cholinergic neurons and interstitial cells of Cajar. These findings suggest that deregulation of gastric emptying might stimulate the ghrelin dynamics and network of gastric cellular communications between nerves and smooth muscle cells.

Research Products

• [Journal Article] Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography: possible relationship between gastroesophageal reflux and metabolic syndrome (2009)
  • Author(s): Iwasaki E, Suzuki H, Sugino Y, Iida T, Nishizawa T, Masaoka T, Hosoda H, Kangawa K, Hibi T.
  • Journal Title: J Gastroenterol Hepatol S2 Pages: 16-21
  • Peer Reviewed
• [Journal Article] Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography : possible relationship between gastroesophageal reflux and metabolic syndrome (2009)
  • Author(s): Iwasaki E, Suzuki H, Sugino Y, Iida T, Nishizawa T, Masaoka T, Hosoda H, Kangawa K, Hibi T
  • Journal Title: J Gastroenterol Hepatol S2 Pages: 16-21
  • Peer Reviewed
• [Journal Article] 胃排出遅延モデルにおけるグレリン動態 (2008)
  • Author(s): 岩崎栄典、鈴木秀和、正岡建洋、鈴木祥子、高橋哲史、西澤俊宏、齋藤義正、菅井恵津子、細田洋司、寒川賢治、日比紀文
  • Journal Title: 消化管運動-目に見えない消化器疾患を追う 10 Pages: 24-26
• [Journal Article] 胃排出遅延モデルにおけるグレリン動態 (2008)
  • Author(s): 岩崎栄典、鈴木秀和、正岡建洋、鈴木祥子、高橋哲史、西澤俊宏、齋藤義正、菅井恵津子、細田洋司、寒川賢治、日比紀文
  • Journal Title: 消化管運動-目にみえない消化器疾患を追う 10 Pages: 24-26
• [Presentation] Enhanced ghrelin secretion and gastric neural network in rats with gastric outlet obstruction (2009)
  • Author(s): Iwasaki E, Suzuki H, et al.
  • Organizer: 2009 International symposium on ghrelin
  • Place of Presentation: 東京
  • Year and Date: 2009-11-18
• [Presentation] 胃排出能障害モデルでのグレリン動態 (2009)
  • Author(s): 岩崎栄典、鈴木秀和、日比紀文
  • Organizer: 第17回日本消化器病学会大会パネルディスカッション3
  • Place of Presentation: 京都
  • Year and Date: 2009-10-14
• [Presentation] 胃排出遅延モデルにおけるグレリン動態とカハールの介在細胞 (2009)
  • Author(s): 岩崎栄典、鈴木秀, 他
  • Organizer: 第11回日本神経消化器病学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-09-25
• [Presentation] Enhanced Ghrelin Secretion and Gastric Excitatory Neural Network in Rats with Gastric Outlet Obstruction (2009)
  • Author(s): Iwasaki E, Suzuki H, et al.
  • Organizer: 米国消化器病学会週間2009 Poster T1779 ( Digestive Disease Week 2009)
  • Place of Presentation: シカゴ
  • Year and Date: 2009-06-02
• [Presentation] Enhanced Ghrelin Secretion and Gastric Excitatory Neural Network in Rats with Gastric Outlet Obstruction (2009)
  • Author(s): Iwasaki E, Suzuki H, et al.
  • Organizer: 米国消化器病学会週間2009 Poster T1779(Digestive Disease Week 2009)
  • Place of Presentation: シカゴ
  • Year and Date: 2009-06-02
• [Presentation] 胃排出障害モデルにおけるグレリン動態と胃の神経-筋連関 (2009)
  • Author(s): 岩崎栄典、鈴木秀和、日比紀文
  • Organizer: 第95回消化器病学会総会シンポジウム3
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-08
• [Presentation] 胃排出障害モデルにおけるグレリン産生・分泌の亢進とc-kit陽性細胞の変化 (2008)
  • Author(s): 岩崎栄典
  • Organizer: 第1回Japan Functional Dyspepsia Research Society
  • Place of Presentation: 日京都
  • Year and Date: 2008-11-08
• [Presentation] 胃排出障害モデルにおけるグレリン産生・分泌の亢進とc-kit陽性細胞の変化 (2008)
  • Author(s): 岩崎栄典
  • Organizer: 第1回Japan Functional Dyspepsia Research Society
  • Place of Presentation: 京都
  • Year and Date: 2008-11-08
• [Presentation] 酸逆流と食道上皮のNADPH oxidase(Nox)発現 (2008)
  • Author(s): 岩崎栄典、鈴木秀和、鈴木祥子、正岡建洋、松崎潤太郎、斎藤義正、西澤俊宏、日比紀文
  • Organizer: 第61回酸化ストレス学会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-20
• [Presentation] Enhanced esophageal NADPH oxidase expression in response to acid (2008)
  • Author(s): Iwasaki, Eisuke ; Suzuki, Hidekazu ; Masaoka, Tatsuhiro ; Nishizawa, Toshihiro ; Takahashi, Tetsufumi ; Saito, Yoshimasa ; Tsugawa, Hitoshi; Hibi, Toshifumi
  • Organizer: 米国消化器病学会週間(Digestive Disease Week2009)
  • Place of Presentation: サンディエゴ
  • Year and Date: 2008-05-20
• [Presentation] Enhanced ghrelin production and secretion and reduced expression of ghrelin receptor in rat stomach with delayed gastric emptying (2008)
  • Author(s): Iwasaki E, Suzuki H, Masaoka T, Nishizawa T, Takahashi T, Tsugawa H, Saito Y, Suzuki S, Hosoda H, Kangawa K, Hibi T.
  • Organizer: 米国消化器病学会週間(Digestive Disease Week 2009)
  • Place of Presentation: 日サンディエゴ
  • Year and Date: 2008-05-18
• [Presentation] Enhanced ghrelin production and secretion and reduced expression of ghrelin receptor in rat stomach with delayed gastric emptying (2008)
  • Author(s): Iwasaki, Eisuke ; Suzuki, Hidekazu ; Masaoka, Tatsuhiro ; Nishizawa, Toshihiro ; Takahashi, Tetsufumi ; Tsugawa, Hitoshi; Saito, Yoshimasa ; Suzuki, Sachiko ; Hosoda, Hiroshi ; Kangawa, Kenji ; Hibi, Toshifumi
  • Organizer: 米国消化器病学会週間(Digestive Disease Week2009)
  • Place of Presentation: サンディエゴ
  • Year and Date: 2008-05-18
• [Presentation] 食後愁訴症候群患者と胃排出障害モデルラットのグレリン動態 (2008)
  • Author(s): 岩崎栄典、鈴木秀和、日比紀文
  • Organizer: 第94回日本消化器病学会シ ンポジウム4
  • Place of Presentation: 青森
  • Year and Date: 2008-05-06
• [Presentation] 食後愁訴症候群患者と胃排出障害モデルラットのグレリン動態 (2008)
  • Author(s): 岩崎栄典、鈴木秀和、日比紀文
  • Organizer: 第94回日本消化器病学会シンポジウム4
  • Place of Presentation: 青森
  • Year and Date: 2008-05-06