| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
In vitro experiments using isolated mouse hepatocytes demonstrated that trans-fatty acid but not cis-fatty acid exacerbates hepatocyte death via increasing mitochondrial oxidative stress, although both cis-fatty acid and trans-fatty acid induces fatty accumulation in hepatocytes. In vivo experiments using obese mice indicated that trans-fatty acid containing diet increases endoplasmic reticulum stress and oxidative stress, followed by hepatocytes ballooning and death whereas cis-fatty acid containing diet induces simple liver steatosis. In conclusion, our findings suggested that trans-fatty acid diet is a potent risk factor of steatohepatitis.
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