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The analysis of relationships of lymphocyte differentiation, gastric mucosal immune response, and carcinogenic mechanism to signaling cascade of TGF-β.

Research Project

Project/Area Number 20790516
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKansai Medical University

Principal Investigator

FUKUI Toshiro  Kansai Medical University, 医学部, 助教 (60402905)

Research Collaborator MIYOSHI Hideaki  関西医科大学, 医学部, 大学院生
FUKATA Norimasa  関西医科大学, 医学部, 大学院生
KOYABU Masaki  関西医科大学, 医学部, 大学院生
OKAZAKI Kazuichi  関西医科大学, 医学部, 教授 (70145126)
MATSUZAKI Koichi  関西医科大学, 医学部, 准教授 (70278638)
UCHIDA Kazushige  関西医科大学, 医学部, 講師 (40411516)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords癌 / 細菌 / シグナル伝達 / 発生・分化 / 免疫学
Research Abstract

We studied the pathway of differentiation from Tn to Th17 or Treg from a standpoint of the different potion of phosphorylation of Smad2/3. However, we could not verify the hypothesis that the different portion of phosphorylation of Smad2/3 was branch point of differentiation. Additionally, the intensive expression of linker-phosphorylated Smad2/3 was observed not in the interstitium, such as immune cells, but in the specific region of the gastrointestinal epithelial cells, which would be relevant to the mucosal proliferation. In future, we will analyze these cells in detail and develop this study results.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (6 results) Book (2 results)

  • [Journal Article] Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases2010

    • Author(s)
      Koyabu M, Uchida K, Miyoshi H, Sakaguchi Y, Fukui T, 他7名
    • Journal Title

      J Gastroenterol (Epub ahead of print)

    • NAID

      10026707041

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Humoral Immune Response in Experimental Autoimmune Pancreatitis in Mice2010

    • Author(s)
      Asada M, Nishio A, Akamatsu T, Tanaka J, Saga K, Kido M, Watanabe N, Uchida K, Fukui T, 他2名
    • Journal Title

      Pancreas 39

      Pages: 224-231

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Humoral Immune Response in Experimental Autoimmune Pancreatitis in Mice2010

    • Author(s)
      Asada M
    • Journal Title

      Pancreas 39

      Pages: 224-231

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases2010

    • Author(s)
      Koyabu M
    • Journal Title

      J Gastroenterol

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic biliary plastic stenting and successful intentional stent retrieval in a benign biliary stricture with mural spherical calcification and porcelain gallbladder2009

    • Author(s)
      Fukui T, 他7名
    • Journal Title

      Intern Med. 48

      Pages: 809-813

    • NAID

      130000121780

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of autoimmune pancreatitis2009

    • Author(s)
      Uchida K, Yazumi S, Nishio A, Kusuda T, Koyabu M, Fukata M, Miyoshi H, Sakaguchi Y, Fukui T, 他3名
    • Journal Title

      J Gastroenterol 44

      Pages: 726-732

    • NAID

      10025176191

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of autoimmune pancreatitis2009

    • Author(s)
      Uchida K
    • Journal Title

      J Gastroenterol 44

      Pages: 726-732

    • NAID

      10025176191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic Biliary Plastic Stenting and Successful Intentional Stent Ret rieval in a Benign Biliary Stricture with Mural Spherical Calcification and Porcelain Gallbladder2009

    • Author(s)
      Fukui T
    • Journal Title

      Intern Med 48(in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【H. pylori感染と上部消化器疾患】病態との関連を巡ってAcid-peptic disorderから腫瘍性疾患までヘリコバクター胃炎におけるCD8陽性細胞の役割-MHC class 2欠損マウスを用いた検討-2008

    • Author(s)
      福井寿朗, 他3名
    • Journal Title

      消化器医学 6

      Pages: 14-20

    • Related Report
      2009 Final Research Report
  • [Journal Article] Recent advances in autoimmune pancreatitis: concept, diagnosis, and pathogenesis2008

    • Author(s)
      Okazaki K, Uchida K, Fukui T.
    • Journal Title

      J Gastroenterol 43

      Pages: 409-418

    • NAID

      10021268863

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gastric mucosal laceration: a complication of manual bag-valve-mask ventilation2008

    • Author(s)
      Fukui T, 他4名
    • Journal Title

      Clin J Gastroenterol 1

      Pages: 56-58

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヘリコバクター胃炎におけるCD8陽性細胞の役割--MHC class 2欠損マウスを用いた検討--2008

    • Author(s)
      福井寿朗
    • Journal Title

      消化器医学 6

      Pages: 14-20

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Gastric mucosal laceration : a complication of manual bag-valve-mask ventilation2008

    • Author(s)
      Fukui T
    • Journal Title

      Clin J Gastroenterol 1

      Pages: 56-58

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 清酒酵母由来チオレドキシンによるインドメサシン胃粘膜障害軽減効果の検討2010

    • Author(s)
      中島淳
    • Organizer
      第6回日本消化管学会総会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-02-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Analysis of Pancreatic and Peripheral Regulatory T Cells in Patients with Autoimmune Pancreatitis2009

    • Author(s)
      Kazushige Uchida
    • Organizer
      DDW2009
    • Place of Presentation
      シカゴ
    • Year and Date
      2009-06-02
    • Related Report
      2009 Final Research Report
  • [Presentation] Analysis of Pancreatic and Peripheral Regulatory T Cells in Patients with Autoimmune Pancreatitis2009

    • Author(s)
      Kazushige Uchida
    • Organizer
      DDW2009
    • Place of Presentation
      CHICAGO, Illinois, USA
    • Year and Date
      2009-05-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] WBN/Kobラットの慢性膵炎・膵外病変における自己免疫性機序の関与及び制御性T細胞の免疫応答2009

    • Author(s)
      坂口雄沢
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-07
    • Related Report
      2009 Final Research Report
  • [Presentation] 制御性T細胞自己免疫性膵炎における制御性T細胞に関する検討2008

    • Author(s)
      三好秀明
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-02
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 自己免疫性膵炎における制御性T細胞に関する検討2008

    • Author(s)
      三好秀明
    • Organizer
      第36回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-17
    • Related Report
      2009 Final Research Report
  • [Book] 見て診て学ぶ膵腫瘍の画像診断2009

    • Author(s)
      岡崎和一、内田一茂、福井寿朗
    • Publisher
      永井書店
    • Related Report
      2009 Final Research Report
  • [Book] 見て診て学ぶ 膵腫瘍の画像診断2009

    • Author(s)
      岡崎和一
    • Publisher
      永井書店
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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