| Project/Area Number |
20790518
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
ASAUMI Hiroshi University of Occupational and Environmental Health, Japan, 医学部, 非常勤助教 (30441835)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 膵線維化 / 膵星細胞 / 活性酸素種(ROS) / 抗酸化物質 / 活性酸素種 / 細胞内活性酸素種 / 低酸素 |
|---|
| Research Abstract |
Pancreatic stellate cells (PSCs)、when activated、synthesize extracellular matrix (ECM) and play a central role of the progression of pancreatic fibrosis. Intracellular reactive oxygen species (ROS) was generated in stimulated quiescent or activated PSCs, and act upstream of as intracellular mediators or second messengers to regulate various signal-transduction pathways. In stimulated PSCs, antioxidants inhibited the intracellular ROS generation, transformation to activated phenotype and ECM synthesis in PSC. Antioxidants could be potential effective against the development of pancreatic fibrosis.
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