Molecular pathogenetic mechanism of idiopathic cardiomyopathy
| Project/Area Number |
20790520
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ARIMURA Takuro Tokyo Medical and Dental University, 難治疾患研究所, 助教 (50342887)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 特発性心筋症 / 肥大型心筋症 / 拡張型心筋症 / 遺伝子変異 / CARP / フクチン / PGM1 / ZASP / Cypher / 心筋Z帯 / 細胞ストレス / ラミンA / C / テストステロン / 心不全 |
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| Research Abstract |
Idiopathic cardiomyopathy (ICM) is heterogeneous myocardial disease associated with functional abnormalities of cardiomyocytes. The aim of this study was to investigate the novel molecular pathogenesis of ICM caused by the genetic abnormalities. As the results, it was identified that (1) mutations in genes encoding CARP and Fukutin are associated with dilated cardiomyopathy (DCM), and (2)ZASP/Cypher anchors PGM1 to Z-disc under conditions of stress and the impaired binding of PGM1 to ZASP/Cypher might be involved in the pathogenesis of DCM.
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] Megakaryoblastic leukemia factor-1gene in the susceptibility to coronary artery disease.2009
Author(s)
Hinohara K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Shibata H, Takahashi TY, Arimura T, Sato A, Naruse T, Ban J, Inoko H, Yamada Y, Sawabe M, Park JE, Izumi T, Kimura A
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Journal Title
Hum. Genet. 126(4)
Pages: 539-47
Related Report
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[Journal Article] Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy.2009
Author(s)
Arimura T, Bos JM, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Moulik M, Doi YL, Towbin JA, Ackerman MJ, Kimura A
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Journal Title
J. Am. Coll. Cardiol 54(4)
Pages: 334-42
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[Journal Article] ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene.2009
Author(s)
Moulik M, Vatta M, Witt SH, Arola AM, Murphy RT, McKenna WJ, Boriek A, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA
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Journal Title
J. Am. Coll. Cardiol 54(4)
Pages: 325-33
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[Journal Article] Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy.2009
Author(s)
Arimura T, Inagaki N, Hayashi T, Shichi D, Sato A, Hinohara K, Vatta M, Towbin JA, Chikamori T, Yamashina A, Kimura A
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Journal Title
Cardiovasc. Res. 83(1)
Pages: 80-8
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[Journal Article] Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations.2008
Author(s)
Hinohara K, Nakajima T, Takahashi M, Hohda S, Sasaoka T, Nakahara K, Chida K, Sawabe M, Arimura T, Sato A, Lee BS, Ban JM, Yasunami M, Park JE, Izumi T, Kimura A
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Journal Title
J. Hum. Genet 53(4)
Pages: 357-9
NAID
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[Presentation] Identification of a novel gene for hypertrophic cardiomyopathy.2009
Author(s)
Arimura T, Bos JM, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Doi YL, Ackerman MJ, Kimura A
Organizer
The 73th Annual Meeting of the Japanese Circulation Society
Place of Presentation
Osaka, Japan
Year and Date
2009-03-22
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