The effect of chemical chaperone on myocardial ischemia-reperfusion injury and infarction in mice

• Project/Area Number: 20790521
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: OKAJIMA Masaki Kanazawa University, 附属病院, 助教 (00361999)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ERストレス / 虚血再灌流 / 心筋梗塞 / シャペロン / シヤペロン

Research Abstract

We assessed the hypothesis that 4-PBA (chemical chaperone) reduces endoplasmic reticulum stress (ER stress) mediated apoptosis and protects against myocardial ischemia-reperfusion injury or myocardial infarction in mice. In result, 4-PBA reduced ER stress mediated apoptosis, decreased infarct size, maintained cardiac function and improved survival ratio in mice with ischemia-reperfusion. On the other hand, 4-PBA inhibited fibrosis and induced cardiac rupture in mice with myocardial infarction.

Research Products

• [Journal Article] (2010)
  • Author(s): Ootsuji, H., Honda, M., Kaneko, S., Usui S., Okajima., M, Okada, H., Sakai, Y., Takamura, T., Horimoto, K., Takamura, M.
  • Journal Title: Circ Cardiovasc Genet 3(1) Pages: 68-77
  • Peer Reviewed
• [Presentation] Sodium 4-phenylbutylate protects against myocardial ischemia-reperfusion injury by reducing unfolded protein response-mediated apoptosis in mice. (2010)
  • Author(s): Okajima, M., Takamura, M., Usui, S., Taniguchi, T., Kanako, S.
  • Organizer: 30th International Symposium on Intensive Care and Emergency Medicine
  • Place of Presentation: Square-Brussels Meeting Center(Belgium)
  • Year and Date: 2010-03-09
• [Presentation] Sodium 4-phenylbutylate protects against myocardial ischemia-reperfusion injury by reducing unfolded protein response-mediated apoptosis in mice. (2010)
  • Author(s): 岡島正樹
  • Organizer: 30^<th> International Symposium on Intensive Care and Emergency Medicine
  • Place of Presentation: Square-Brussels Meeting Center (Brussels, Belgium)
  • Year and Date: 2010-03-09
• [Presentation] Sodium 4-phenylbutylate protects against myocardial ischemia-reperfusion injury by reducing unfolded protein response-mediated apoptosis in mice. (2010)
  • Author(s): 岡島正樹, 近田明男, 八重樫貴紀, 池田達則, 高島伸一郎, 加藤武史, 薄井荘一郎, 古荘浩司, 金子周一
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-03-05
• [Presentation] Sodium 4-phenylbutylate protects against myocardial ischemia-reperfusion injury by reducing unfolded protein response-mediated apoptosis in mice. (2010)
  • Author(s): 岡島正樹
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-03-05
• [Presentation] Sodium 4-phenylbutylate reduces myocardial ischemia-reperfusion injury in mice. (2008)
  • Author(s): Okajima, M., Takamura, M., Kaneko S.
  • Organizer: Hypertension 2008 (ESH/ISH)
  • Place of Presentation: Internationales Congress Centrum Berlin (Germany)
  • Year and Date: 2008-06-18
• [Presentation] Sodium 4-phenylbutylate reduces myocardial ischemia-reperfusion injury in mice. (2008)
  • Author(s): 岡島正樹
  • Organizer: Hypertension 2008 (ESH/ISH)
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2008-06-18