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Exercise tolerance and left ventricular diastolic function during exercise in patients with diastolic heart failure

Research Project

Project/Area Number 20790524
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionMie University

Principal Investigator

MASAKI Tanabe  Mie University, 医学部・附属病院, 助教 (50456737)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords心エコー / スペックルトラッキング法 / 運動負荷 / 臥位エルゴメーター / 拡張期心不全 / 左室拡張能 / 運動耐容能 / E / E' / 労作時呼吸困難
Research Abstract

Cardiac performance during exercise was evaluated using novel echocardiographic techniques in normal subjects. All datasets from parasternal views were obtained. Speckle tracking imaging datasets from apical views were analyzed in 8 of 10 subjects. During exercise, cardiac output and E/e' increased with exercise stress. On the other hand, stroke volume and global systolic strain did not change with exercise. Cardiac performance during exercise can be evaluated, and has potential for clinical applications.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] Left Ventricular Contraction-Relaxation Coupling in Normal, Hypertrophic, and Failing Myocardium Quantified by Speckle-Tracking Global Strain and Strain Rate Imaging.2010

    • Author(s)
      Takamura T, Dohi K, Onishi K, Tanabe M, Sugiura E, Nakajima H, Ichikawa K, Nakamura M, Nobori T, Ito M.
    • Journal Title

      J Am Soc Echocardiogr. (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Quantifying the role of regional dyssynchrony on global left ventricular performance2009

    • Author(s)
      Lamia B, Tanabe M, Kim Hk, Johnson L, Gorcsan J, Pinsky MR.
    • Journal Title

      JACC Cardiovasc Imaging 2

      Pages: 1350-1356

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated cardiac troponin I and relationship to persistence of electrocar diographic and echocardiographic abnormalities after aneurysmal subarachnoid hemorrhage.2009

    • Author(s)
      Hravnak M.Frangiskakis JM.Crago EA.Chang Y.Tanabe M.Gorcsan J.Horowitz MB.
    • Journal Title

      Stroke 40

      Pages: 3478-3484

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ventricular arrhythmia risk after subarachnoid hemorrhage.2009

    • Author(s)
      Frangiskakis JM, Hravnak M, Crago EA, Tanabe M, Kip KE, Gorcsan J, Horowitz MB, Kassam AB, London B.
    • Journal Title

      Neurocrit Care 10

      Pages: 287-294

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Echocardiographic speckle tracking radial strain imaging to assess ventricular dyssynchrony in a pacing model of resynchronization therapy2008

    • Author(s)
      Tanabe M, Lamia B, Tanaka H, Schwartzman D, Pinsky MR, Gorcsan J.
    • Journal Title

      J Am Soc Echocardiogr 21

      Pages: 1382-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of elevation in cardiac troponin I to clinical severity, cardiac dysfunction, and pulmonary congestion in patients with subarachnoid hemorrhage.2008

    • Author(s)
      Tanabe M, Crago EA, Suffoletto MS, Hravnak M, Frangiskakis JM, Kassam AB , Horowitz MB, Gorcsan J
    • Journal Title

      Am J Cardiol 102

      Pages: 1545-50

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic characteristics of patients with diastolic heart failure and hypertension.2008

    • Author(s)
      Fujimoto N, Onishi K, Dohi K, Tanabe M, Kurita T, Takamura T, Yamada N, Nobori T, Ito M.
    • Journal Title

      Hypertens Res 31

      Pages: 1727-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] スペックルトラッキング法を用いた臥位エルゴメーター運動負荷時の血行動態評価.2010

    • Author(s)
      杉本匡史、田辺正樹、土肥薫、市川和秀、中嶋寛、大西勝也、山田典一、宮原眞敏、中村真潮、登勉、伊藤正明
    • Organizer
      第21回日本心エコー図学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2010-05-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Cardiac Performance During Supine Ergometer Exercise Evaluated by Tissue Doppler and Speckle Tracking Echocardiography.2010

    • Author(s)
      Sugimoto T, Tanabe M, Dohi K, Ichikawa K, Nakajima H, Onishi K, Yamada N, Miyahara M, Nakamura M, Ito M.
    • Organizer
      The 74th Annual Scientific Meeting of the Japanese Circulation Society.
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Cardiac Performance during Supine Ergometer Exercise Evaluated by Tissue Doppler and Speckle Tracking Echocardiography2010

    • Author(s)
      Sugimoto T, Tanabe M, Dohi K, Ichikawa K, Nakajima H, Ohnishi K, Yamada N, Miyahara M, Nakamura M, Itoh M
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 循環器内科入院患者における閉塞性換気障害の合併頻度2009

    • Author(s)
      田辺正樹、大西勝也、仲田智之、中嶋寛、土肥薫、山田典一、宮原眞敏、中村真潮、伊藤正明
    • Organizer
      第57回日本臓病学会総会・学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 左室拡張機能低下例において呼吸機能障害は高率に合併する2008

    • Author(s)
      田辺正樹、大西勝也、土肥薫、高村武志、小川英美喜、宮原眞敏、中村真潮、伊藤正明
    • Organizer
      第56回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 左室拡張能障害、閉塞性換気障害の年齢、性別による相違2008

    • Author(s)
      田辺正樹、大西勝也、土肥薫、高村武志、小川英美喜、宮原眞敏、中村真潮、伊藤正明
    • Organizer
      第56回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Variability of systolic and diastolic function in atrial fibrillation2008

    • Author(s)
      Senga M, Tanabe M, Takamura T, Dohi K, Fujii E, Onishi K, Ito M
    • Organizer
      第12回日本心不全学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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