| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
In this study, to elucidate the possibility of TRPC ion channels as new therapeutic targets in the treatment of cardiac diseases, we applied TRPC inhibitors to several mice model of cardiac hypertrophy or heart failure. We found that TRPC inhibitors ameliorate the pathological cardiac hypertrophy in mice with cardiac hypertrophy. We also found that the cardioprotective hormone, atrial natriuretic peptide inhibits TRPC3/6 channel activities. Our study revealed the potential significance of TRPCs as novel therapeutic targets in the treatment of pathological cardiac remodeling.
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