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The role of Angiopoietin-1/Tie2 signaling pathway in pulmonary arterial hypertension.

Research Project

Project/Area Number 20790528
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionOsaka University

Principal Investigator

KURODA Tadashi  Osaka University, 医学系研究科, 寄附講座助教 (60403078)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsangiopoietin-1(Ang1) / Tie2 / Gabファミリー蛋白質 / 肺高血圧症 / MAPキナーゼ / AKT / シグナル伝達 / 相補性 / angiopoietin-1 / ERK1 / 2
Research Abstract

It has been reported that angiopoietin-1(Ang1)/Tie2 signaling pathway has an essential role in the pathogenesis of pulmonary arterial hypertension (PAH). Here, we investigated the role of Gab family proteins in the Ang1/Tie2 signaling pathway. We found that both Gab1 and Gab2 have redundant roles for activation of ERK1/2 and AKT downstream of Ang1/Tie2 pathway in the endothelial cells. In addition, we have created the inducible endothelium-specific Gab1/Gab2 double knockout mice through crossing Gab1flox/flox Gab2-/- mice with VE-CadCreERT2 mice.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (13 results)

All 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Remarks (3 results)

  • [Journal Article] SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene2010

    • Author(s)
      Nakaoka Y, Shioyama W, Kunimoto S, Arita Y, Higuchi K, Yamamoto K, Fujio Y, Nishida K, Kuroda T, Hirota H, Yamauchi-Takihara K, Hirano T, Komuro I, Mochizuki N.
    • Journal Title

      J Mol Cell Cardiol

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene2010

    • Author(s)
      Nakaoka Y, et al.
    • Journal Title

      Journal of Molecular and Cellular Cardiology (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary arterial hypertension2009

    • Author(s)
      Hiramoto Y, Shioyama W, Higuchi K, Arita Y, Kuroda T, Sakata Y, Nakaoka Y, Fujio Y, Yamauchi-Takihara K.
    • Journal Title

      J Cardiol 53(3)

      Pages: 374-80

    • NAID

      10025183776

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of Plasma Endothelin-1 Level after Bosentan Administration in Pulmonary Arterial Hypertension2009

    • Author(s)
      Hiramoto, et.al.
    • Journal Title

      Journal of Cardiology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Docking Protein Gab1 is Essential for HGF-dependent Endothelial Signaling and Angiogenesis after Hindlimb Ischemia2009

    • Author(s)
      Shioyama W, Higuchi K, Hiramoto Y, Arita Y, Kuroda T, Fujio Y, Sanada F, Taniyama Y, Morishita R, Yamauchi-Takihara K, Hirano T, Hori M, Mochizuki N, Nakaoka Y.
    • Organizer
      第73回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Scaffolding Docking Protein Gab1 is Essential for HGF-dependent Endothelial Signaling and Angiogenesis after Hindlimb Ischemia2008

    • Author(s)
      Shioyama W, Higuchi K, Okamoto K, Arita Y, Sanada F, Taniyama Y, Morishita R, Kuroda T, Fujio Y, Yamauchi-Takihara K, Mochizuki N, Nakaoka Y.
    • Organizer
      American Heart Association Scientific Sessions 2008
    • Place of Presentation
      New Ohleans
    • Year and Date
      2008-11-12
    • Related Report
      2009 Final Research Report
  • [Presentation] ドッキング蛋白質Gab1は下肢虚血ストレス後の血管新生に必須である2008

    • Author(s)
      中岡良和、樋口香織、塩山渉、岡本紀太郎、有田陽、黒田忠、眞田文博、谷山義明、森下竜一、藤尾慈、瀧原圭子、平野俊夫、望月直樹
    • Organizer
      第12回Molecular Cardiovascular Conference
    • Place of Presentation
      北海道余市郡赤井川村
    • Year and Date
      2008-09-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Accuracy and efficiency of a novel diagnusfic method for non-invasive coronary angiography using 64-slice multi-slice computed tomography2008

    • Author(s)
      黒田忠、角辻暁、小谷順一、橘公一、辻井健一、南都伸介
    • Organizer
      第17回心血管インターベンション学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-07-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Accuracy and Efficacy of a novel diagnostic method for non-invasive Coronary angiography using 64-slice multi-slice computed tomography2008

    • Author(s)
      Kuroda, et.al
    • Organizer
      TCT Asia Pacific 2008
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2008-04-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Essential role of Gab2 for Angiopoietin-1/Tie2-dependent Signaling and Cytoprotection in the Endothelial Cells2008

    • Author(s)
      Okamoto K, Shioyama W, Higuchi K, Kuroda T, Fujio Y, Yamauchi-Takihara K, Hori M, Koh GY, Mochizuki N, Nakaoka Y
    • Organizer
      第72回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/cardiology/27research/2784res.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/cardiology/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/imed3/lab_heart/

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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