Role of microRNA in the development of atherosclerosis

• Project/Area Number: 20790531
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Okayama University
• Principal Investigator: MIYOSHI Toru Okayama University, 大学院・医歯薬学総合研究科, 助教 (70444651)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: マイクロRNA / 動脈硬化 / 炎症

Research Abstract

The precise mechanisms of atherosclerosis remain unknown. We investigate the role of microRNAs, which is new regulator of the gene expression, in the macrophage. We found that the treatment of oxidized LDL resulted in the change in expression of eight microRNAs.

Research Products

• [Journal Article] I mpact of olmesartan on progression of coronary atherosclerosis a serial volumetric intravascular ultrasound analysis from the OLIVUS (impact of OLmesarten on progression of coronary atherosclerosis: evaluation by intravascular ultrasound) trial. (2010)
  • Author(s): Hirohata A, Yamamoto K, Miyoshi T, Hatanaka K, Hirohata S, Yamawaki H, Komatsubara I, Murakami M, Hirose E, Sato S, Ohkawa K, Ishizawa M, Yamaji H, Kawamura H, Kusachi S, Murakami T, Hina K, Ohe T.
  • Journal Title: J Am Coll Cardiol. 55(10) Pages: 976-982
  • Peer Reviewed
• [Journal Article] S erum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound. (2010)
  • Author(s): Miyoshi T, Onoue G, Hirohata A, Hirohata S, Usui S, Hina K, Kawamura H, Doi M, Kusano KF, Kusachi S, Ninomiya Y.
  • Journal Title: Atherosclerosis. (in press)
  • Peer Reviewed
• [Journal Article] C ardio-ankle vascular index is independently associated with the severity of coronary atherosclerosis and left ventricular function in patients with ischemic heart disease. (2010)
  • Author(s): Miyoshi T, Doi M, Hirohata S, Sakane K, Kamikawa S, Kitawaki T, Kaji Y, Kusano KF, Ninomiya Y, Kusachi S.
  • Journal Title: J Atheroscler Thromb. 17(3) Pages: 249-258
  • Peer Reviewed
• [Journal Article] Cardio-ankle vascular index is independently associated with the severity of coronary atherosclerosis and left ventricular function in patients with ischemic heart disease. (2010)
  • Author(s): 三好亨
  • Journal Title: J Atheroscler Thromb 17 Pages: 249-258
  • Peer Reviewed
• [Journal Article] A ugmentation index is associated with B-type natriuretic peptide in patients with paroxysmal atrial fibrillation. (2009)
  • Author(s): Kaji Y, Miyoshi T, Doi M, Hirohata S, Kamikawa S, Sakane K, Kitawaki T, Kusachi S, Kusano KF, Ito H.
  • Journal Title: Hypertens Res. 32(7) Pages: 611-616
  • Peer Reviewed
• [Journal Article] A DAMTS1 is a unique hypoxic early response gene expressed by endothelial cells. (2009)
  • Author(s): Hatipoglu OF, Hirohata S, Cilek MZ, Ogawa H, Miyoshi T, Obika M, Demircan K, Shinohata R, Kusachi S, Ninomiya Y.
  • Journal Title: J Biol Chem. 284(24) Pages: 16325-16333
  • Peer Reviewed
• [Journal Article] I ncreased augmentation index of the radial pressure waveform in patients with paroxysmal atrial fibrillation. (2009)
  • Author(s): Doi M, Miyoshi T, Hirohata S, Iwabu A, Tominaga Y, Kaji Y, Kamikawa S, Sakane K, Kitawaki T, Kusano KF, Kusachi S.
  • Journal Title: Cardiology. 113(2) Pages: 138-145
  • Peer Reviewed
• [Journal Article] Hyaluronan Receptors Involved in Cytokine Induction in Monocytes (2009)
  • Author(s): Yamawaki H, Hirohata S, Miyoshi T, Takahashi K, Ogawa H, Shinohata R, Dmircan K, Kusachi S, Yamamoto K, Ninomiya Y
  • Journal Title: Glycobiology 19 Pages: 83-92
  • Peer Reviewed
• [Journal Article] siRNA silencing reveals role of vascular cell adhesion molecule-1 in vascular smooth muscle cell migration (2008)
  • Author(s): Petersen EJ, Miyoshi T, Yuan Z, Hirohata S, Li JZ, Shi W, Angle JF.
  • Journal Title: Atherosclerosis 198 Pages: 301-306
  • Peer Reviewed
• [Journal Article] Quantitativc trait locus analysis of circulating adhesion molecules in hyperlipidemic apolipoprotein E-deficient mice (2008)
  • Author(s): Yuan Z, Su Z, Miyoshi T, Rowlan JS, Shi W.
  • Journal Title: Molecular Genetics and Genomics 280 Pages: 375-383
  • Peer Reviewed
• [Presentation] The association of serum adipocyte fatty acid binding protein with coronary atherosclerotic burden measured by intravascular ultrasound (2009)
  • Author(s): 三好亨
  • Organizer: 欧州心臓学会議2009
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2009-09-02
• [Presentation] ADAMTS-1 is an endothelial cell-specific hypoxia-inducible gene (2009)
  • Author(s): 三好亨, 他
  • Organizer: 第82回米国心臓協会学術集会
  • Place of Presentation: 米国、オーランド
• [Presentation] A novel cationic protein reduced infracted size and protected myocytes from oxidative stress through modification of Akt signaling (2009)
  • Author(s): 三好亨, 他
  • Organizer: 第82回米国心臓協会学術集会
  • Place of Presentation: 米国、オーランド
• [Presentation] Combination therapy of angiotensin II receptor blockers plus a calcium channel blocker, but not a diuretic, improve late systolic pressure augmentation in elderly patients with essential hypertension (2009)
  • Author(s): 三好亨, 他
  • Organizer: 欧州心臓学会議
  • Place of Presentation: スペイン、バルセロナ
• [Presentation] The association of serum adipocyte fatty acid binding protein with coronary atherosclerotic burden measured by intravascular ultrasound (2009)
  • Author(s): 三好亨, 他
  • Organizer: 欧州心臓学会議
  • Place of Presentation: スペイン、バルセロナ
• [Presentation] Arterial stiffness is an independent determinant of B-type natriuretic peptide in patients with paroxysmal atrial fibrillation (2009)
  • Author(s): 三好亨, 他
  • Organizer: 欧州心臓学会議
  • Place of Presentation: スペイン、バルセロナ
• [Presentation] Serum Adipocytc Fatty acid-binding protein level are independently associated with Coronary atherosclerosis (2008)
  • Author(s): Miyoshi T, Hirohata A, Usui S, Yamamoto K, Hina K, Hirohata S, Kusachi S, Yoshifumi N, Kengo K
  • Organizer: American Heart Association, scientific sessions 2008
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2008-11-11