| Project/Area Number |
20790532
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
SUZUKI Jun Ehime University, 大学院・医学系研究科, 講師 (40452693)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 分子血管病態学 / 動脈硬化 / プラーク破碇 / アンジオテンシン / マクロファージ / 酸化ストレス / プラーク破綻 |
|---|
| Research Abstract |
The incidence of plaque rupture was significantly reduced in Apolipoprotein E (ApoE)/Angiotensin II type 1a receptor (AT_<1a>R) double knockout mice compared with ApoE knockout mice. Lipid accumulation, macrophage infiltration into the plaque, superoxide anion production, and matrix metalloproteinase activity were markedly attenuated in ApoE/AT_<1a>R knockout mice compared with ApoE knockout mice. These findings suggest that AT_<1a>R blocking could decrease the incidence of atherosclerotic plaque rupture, and that AT_<1a>R mediated inflammation, oxidative stress, and MMP activation may have an important role in plaque vulnerability.
|
