Investigation into modifying factors in patients with hypertrophic cardiomyopathy caused by an identical disease-causing mutation

• Project/Area Number: 20790533
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kochi University
• Principal Investigator: KUBO Toru Kochi University, 教育研究部医療学系, 助教 (80325422)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 臨床心血管病態学 / 肥大型心筋症 / 遺伝子 / 臨床

Research Abstract

I investigated the genotype-phenotype correlations in hypertrophic cardiomyopathy (HCM). In genetic analysis, I reported some mutations associated with HCM, particularly mutations in cardiac myosin-binding protein C gene. In the studies of clinical phenotype in HCM, I focused on the left ventricular remodeling of this disease and reported several results including the usefulness of biomarkers for predicting the prognosis.

Research Products

• [Journal Article] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcome in hypertrophic cardiomyopathy. (2011)
  • Author(s): Kubo T, Kitaoka H, Matsumura Y, 他9名
  • Journal Title: Circ J 75 Pages: 919-926
  • NAID: 10028103447
  • Peer Reviewed
• [Journal Article] Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-based Japanese population: results from Kochi RYOMA study. (2010)
  • Author(s): Kubo T, Kitaoka H, Okawa M, 他6名
  • Journal Title: J Cardiol 56 Pages: 314-319
  • NAID: 10028189621
  • Peer Reviewed
• [Journal Article] Hypertrophic cardiomyopathy in the elderly. (2010)
  • Author(s): Kubo T, Kitaoka H, Okawa M, Nishinaga M, Doi YL
  • Journal Title: Geriatr Gerontol Int 10 Pages: 9-16
  • NAID: 10027271465
  • Peer Reviewed
• [Journal Article] Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction, and male gender in hypertrophy cardiomyopathy (2010)
  • Author(s): Kubo T, Kitaoka H, Okawa M, 他9名
  • Journal Title: Clin Cardiol 3 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy. (2010)
  • Author(s): Kubo T, Kitaoka H, Terauchi Y, 他5名
  • Journal Title: J Cardiol 55 Pages: 125-129
  • NAID: 10027051736
  • Peer Reviewed
• [Journal Article] Plasma adiponectin levels and left ventricular remodeling in hypertrophic cardiomyopathy (2010)
  • Author(s): Kitaoka H, Kubo T, Okawa M, 他4名
  • Journal Title: Int Heart J 51 Pages: 51-55
  • NAID: 130000162396
  • Peer Reviewed
• [Journal Article] Clinical features of the dilated phase of hypertrophic cardiomyopathy in comparison with those of dilated cardiomyopathy. (2010)
  • Author(s): Hamada T, Kubo T, Kitaoka H, 他10名
  • Journal Title: Clin Cardiol 33 Pages: 24-28
  • Peer Reviewed
• [Journal Article] A frameshift deletion mutation in the cardiac myosin-binding protein C gene associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy. (2010)
  • Author(s): Hitomi N, Kubo T, Kitaoka H, 他7名
  • Journal Title: J Cardiol 56 Pages: 189-196
  • NAID: 10027704207
  • Peer Reviewed
• [Journal Article] A novel cardiac myosin-binding prote in C S297X mutation in hypertrophic cardiomyopathy. (2010)
  • Author(s): Hirota T, Kubo T, Kitaoka H, 他8名
  • Journal Title: J Cardiol 56 Pages: 59-65
  • Peer Reviewed
• [Journal Article] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcome in hypertrophic cardiomyopathy (2010)
  • Author(s): Kubo T, Kitaoka H, Okawa M, et al.
  • Journal Title: Circulation Journal Volume: 75 Pages: 919-926
  • NAID: 10028103447
  • Peer Reviewed
• [Journal Article] Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-based Japanese population : results from Kochi RYOMA study. (2010)
  • Author(s): Kubo T, Kitaoka H, Okawa M, et al.
  • Journal Title: Journal of Cardiology Volume: 56 Pages: 314-319
  • NAID: 10028189621
  • Peer Reviewed
• [Journal Article] Clinical features of dilated phase of hypertrophic cardiomyopathy in Comparison with those of dilated cardiomyopathy. (2010)
  • Author(s): Hamada T, Kubo T, Kitaoka H, et al.
  • Journal Title: Clinical Cardiology Volume: 33
  • Peer Reviewed
• [Journal Article] A frameshift deletion mutation in the cardiac myosin-binding protein C gene associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy. (2010)
  • Author(s): Hitomi N, Kubo T, Kitaoka H, et al.
  • Journal Title: Journal of Cardiology Volume: 56 Pages: 189-196
  • NAID: 10027704207
  • Peer Reviewed
• [Journal Article] Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy. (2010)
  • Author(s): Kitaoka H, Kubo T, Okawa M, et al.
  • Journal Title: Circulation Journal Volume: 74 Pages: 1191-1196
  • NAID: 10026474877
  • Peer Reviewed
• [Journal Article] A novel cardiac myosin-binding protein C S294X mutation in hypertrophic cardiomyopathy. (2010)
  • Author(s): Hirota T, Kubo T, Kitaoka H, el al.
  • Journal Title: Journal of Cardiology Volume: 56 Pages: 59-65
  • Peer Reviewed
• [Journal Article] Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction, and male gender in hypertrophy cardiomyopathy. (2010)
  • Author(s): Kubo T, Kitaoka H, Okawa M, et al.
  • Journal Title: Clinical Cardiology 33
  • Peer Reviewed
• [Journal Article] Plasma adiponectin levels and left ventricular remodeling in hypertrophic cardiomyopathy. (2010)
  • Author(s): Kitaoka H, Kubo T, Okawa M, et al.
  • Journal Title: International Heart Journal 51 Pages: 51-55
  • NAID: 130000162396
  • Peer Reviewed
• [Journal Article] Hypertrophic cardiomyopathy in the elderly. (2010)
  • Author(s): Kubo T, Kitaoka H, Okawa M, et al.
  • Journal Title: Geriatrics and Gerontology International 10 Pages: 9-16
  • NAID: 10027271465
  • Peer Reviewed
• [Journal Article] Clinical features of dilated phase of hypertrophic cardiomyopathy in Comparison with those of dilated cardiomyopathy. (2010)
  • Author(s): Hamada T, Kubo T, Kitaoka H, et al.
  • Journal Title: Clinical Cardiology (印刷中)
  • Peer Reviewed
• [Journal Article] A novel cardiac myosin-binding protein C S294X mutation in hypertrophic cardiomyopathy. (2010)
  • Author(s): Hirota T, Kubo T, Kitaoka H, et al.
  • Journal Title: Journal of Cardiology (印刷中)
  • Peer Reviewed
• [Journal Article] Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy. (2010)
  • Author(s): Kubo T, Kitaoka H, Terauchi Y, et al.
  • Journal Title: Journal of Cardiology 55 Pages: 125-129
  • NAID: 10027051736
  • Peer Reviewed
• [Journal Article] Clinical impact of atrial fibrillation in patients with hypertrophic cardiomyopathy.Results from Kochi RYOMA Study (2009)
  • Author(s): Kubo T, Kitaoka H, Okawa M, 他7名
  • Journal Title: Circ J 73 Pages: 1599-1600
  • Peer Reviewed
• [Journal Article] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype .comparison of pure-apical form and distal-dominant form. (2009)
  • Author(s): Kubo T, Kitaoka H, Okawa M, 他9名
  • Journal Title: Circ J 73 Pages: 2330-2336
  • NAID: 10025938627
  • Peer Reviewed
• [Journal Article] Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophy cardiomyopathy. (2009)
  • Author(s): Arimura T, Bos JM, Sato A, Kubo T, 他9名
  • Journal Title: J Am Coll Cardiol 54 Pages: 334-342
  • Peer Reviewed
• [Journal Article] Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardiomyopathy: comparison with B-type natriuretic peptide. (2009)
  • Author(s): Kitaoka H, Kubo T, Okawa M, 他5名
  • Journal Title: J Cardiol 53 Pages: 361-367
  • NAID: 10025183733
  • Peer Reviewed
• [Journal Article] Clinical impact of atrial fibrillation in patients with hypertrophic cardiomyopathy. Results fro Kochi RYOMA Study. (2009)
  • Author(s): Kubo T, Kitaoka H, Okawa M, et al.
  • Journal Title: Circulation Journal 73 Pages: 1599-1605
  • Peer Reviewed
• [Journal Article] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype : Comparison of pure-apical form and distal-dominant form. (2009)
  • Author(s): Kubo T, Kitaoka H, Okawa M, et al.
  • Journal Title: Circulation Journal 73 Pages: 2330-2336
  • NAID: 10025938627
  • Peer Reviewed
• [Journal Article] Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardiomyopathy : comparison with B-type natriuretic peptide. (2009)
  • Author(s): Kitaoka H, Kubo T, Okawa M, et al.
  • Journal Title: Journal of Cardiology 53 Pages: 361-367
  • NAID: 10025183733
  • Peer Reviewed
• [Journal Article] Cardiac ankyrin repeat protein gene(ANKRD1)mutations in hypertrophic cardiomyopathy. (2009)
  • Author(s): Arimura T, Bos JM, Sato A, Kubo T, et al.
  • Journal Title: Journal of American College of Cardiology 54 Pages: 334-342
  • Peer Reviewed
• [Journal Article] Clinical impact of atrial fibrillation in patients with hypertrophic cardiomyopathy : results from Kochi RYOMA Study (2009)
  • Author(s): Kubo T, Kitaoka H, Okawa M, et.al.
  • Journal Title: Circulation Journal (印刷中)
  • NAID: 10025934646
  • Peer Reviewed
• [Journal Article] Clinical features of dilated phase of hypertrophic cardiomyopathy in comparison with those of dilated cardiomyopathy (2009)
  • Author(s): Hamada T, KuboT, Kitaoka H, et.al.
  • Journal Title: Clinical Cardiology (印刷中)
  • Peer Reviewed
• [Journal Article] Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardioniyopathy : Comparison with B-type natriuretic peptide (2009)
  • Author(s): Kitaoka H, Kubo T, Okawa M, et.al.
  • Journal Title: Journal of Cardiology (印刷中)
  • Peer Reviewed
• [Journal Article] A case report : hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy (2009)
  • Author(s): KuboT, Kitaoka H, Terauchi Y, et.al.
  • Journal Title: Journal of Cardiology (印刷中)
  • Peer Reviewed
• [Journal Article] Hypertrophic cardiomyopathy with mild left ventricular remodeling: echocardiographic assessment using left ventricular wall motion score. (2008)
  • Author(s): Hayato K, Okawa M, Matsumura Y, Kitaoka H, Kubo T, 他7名
  • Journal Title: J Cardiol 51 Pages: 92-105
  • NAID: 10024420958
  • Peer Reviewed
• [Journal Article] Hypertrophic cardiomyopathy with mild left ventricular remodeling : echocardiographic assessment using left ventricular wall motion score. (2008)
  • Author(s): Hayato K, Okawa M, Matsumura Y, Kitaoka H, Kubo T, et.al.
  • Journal Title: Journal of Cardiology 51 Pages: 95-105
  • NAID: 10024420958
  • Peer Reviewed
• [Journal Article] Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy.
  • Author(s): Kitaoka H, Kubo T, Okawa M, 他4名
  • Journal Title: Circ J 74 Pages: 1191-1196
  • NAID: 10026474877
  • Peer Reviewed
• [Presentation] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy (2010)
  • Author(s): Kubo T
  • Organizer: ESC CONGRESS 2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-08-30
• [Presentation] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy. (2010)
  • Author(s): Kubo T
  • Organizer: ESC CONGRESS 2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-08-30
• [Presentation] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy (2010)
  • Author(s): Kubo T
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-22
• [Presentation] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy (2010)
  • Author(s): Kubo T
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 京都国際会議場(京都府)
• [Presentation] Gender differences in the clinical features of hypertrophic cardiomyopathy in an unselected regional Japanese population: Results from Kochi RYOMA study (2009)
  • Author(s): 久保亨
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-30
• [Presentation] 肥大型心筋症患者の病因遺伝子スクリーニング:重複遺伝子変異とその臨床的意義 (2009)
  • Author(s): 久保亨
  • Organizer: 第54回日本人類遺伝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-24
• [Presentation] 地域在住高齢心筋症患者の病態に関する検討 (2009)
  • Author(s): 久保亨
  • Organizer: 第51回日本老年医学会学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-06-20
• [Presentation] Cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction and male gender in hypertrophic Cardiomyopathy (2009)
  • Author(s): Kubo T
  • Organizer: 17th Asian Pacific Congress of Cardiology
  • Place of Presentation: 京都
  • Year and Date: 2009-05-20
• [Presentation] Impact of atrial fibrillation in elderly patients with hypertrophic cardiomyopathy (2009)
  • Author(s): Kubo T
  • Organizer: 17th Asian Pacific Congress of Cardiology
  • Place of Presentation: 京都
  • Year and Date: 2009-05-20
• [Presentation] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype: comparison of pure-apical from and distal-dominant form (2009)
  • Author(s): 久保亨
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Genetic screening and compound mutations in patients with hypertrophic cardiomyopathy (2009)
  • Author(s): 久保亨
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Clinical profiles of hypertrophic cardiomyopathy with apical phenotype : comnarison of nure-anical from and distal-dominant form (2009)
  • Author(s): 久保亨
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪大阪国際会議場
  • Year and Date: 2009-03-22
• [Presentation] Genetic screening and compound mutations in patients with hypertrophic cardiomyopathy (2009)
  • Author(s): 久保亨
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪リーガロイヤルホテル
  • Year and Date: 2009-03-20
• [Presentation] Cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction and male gender in hypertrophic Cardiomyopathy. (2009)
  • Author(s): Kubo T
  • Organizer: 17^<th> Asian Pacific Congress of Cardiology
  • Place of Presentation: 京都国際会議場(京都府)
• [Presentation] Impact of atrial fibrillation in elderly patients with hypertrophic cardiomyopathy. (2009)
  • Author(s): Kubo T
  • Organizer: 17^<th> Asian Pacific Congress of Cardiology
  • Place of Presentation: 京都国際会議場(京都府)
• [Presentation] 地域在住高齢心筋症患者の病態に関する検討 (2009)
  • Author(s): 久保亨
  • Organizer: 第51回日本老年医学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 肥大型心筋症患者の病因遺伝子スクリーニング:重複遺伝子変異とその臨床的意義 (2009)
  • Author(s): 久保亨
  • Organizer: 第54回日本人類遺伝学会学術集会
  • Place of Presentation: グランドプリンスホテル高輪(東京都)
• [Presentation] Gender differences in the clinical features of hypertrophic cardiomyopathy in an unselected regional Japanese population : Results from Kochi RYOMA study. (2009)
  • Author(s): 久保亨
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Book] 循環器疾患最新の治療2010-2011 (2010)
  • Author(s): 久保亨、土居義典, 他
  • Publisher: 南江堂
• [Book] 循環器病学基礎と臨床 (2010)
  • Author(s): 久保亨、大川真理、北岡裕章、土居義典, 他
  • Publisher: 西村書店
• [Book] 循環器疾患最新の治療2010-2011 (2010)
  • Author(s): 久保亨、土居義典
  • Publisher: 南江堂
• [Book] 循環病学基礎と臨床 (2010)
  • Author(s): 久保亨、大川真理、北岡裕章、土居義典
  • Publisher: 西村書店
• [Book] 新しい診断と治療のABC心筋症 (2008)
  • Author(s): 久保亨、北岡裕章、土居義典, 他
  • Publisher: 最新医学社
• [Book] 循環器科循環器疾患の発症・増悪関連遺伝子最近の話題 (2008)
  • Author(s): 久保亨、土居義典, 他
  • Publisher: 科学評論社
• [Book] 新しい診断と治療のABC心筋症 (2008)
  • Author(s): 久保亨、北岡裕章、土居義典
  • Total Pages: 6
  • Publisher: 最新医学社
• [Book] 循環器科循環器疾患の発症・増悪関連遺伝子最近の話題 (2008)
  • Author(s): 久保亨、土居義典
  • Total Pages: 5
  • Publisher: 科学評論社