New target of chronic heart failure treatment by cholinesterase inhibitor (donepezil)
| Project/Area Number |
20790534
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
HANDA Takemi Kochi University, 医学部附属病院, 医員 (00437716)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 分子心臓病態学 / 循環器・心不全 / 心筋梗塞 / リモデリング抑制 / ANPmRNA活性化 / アセチルコリン |
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| Research Abstract |
We reported that the mechanism of cholinesterase inhibitor (donepezil) for chronic heart failure (CHF) treatment. 1. Donepezil activated PI3K/Akt/HIF/VEGF cell survival pathway. 2. Donepezil induced HIF under CHF condition, and HIF activated myocardial ANPmRNA expression which induced natriuretic effects.
This study suggested that ANPmRNA expression induced by donepezil protected myocardium under hypoxic condition.
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Report
(3 results)
Research Products
(15 results)
