Oxidative DNA damage and its defense mechanism in atherosclerosis
| Project/Area Number |
20790535
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
鳥巣 久美子 Kyushu University, 生体防御医学研究所, (非常勤研究員) (20448434)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 分子血管病態学 / 動脈硬化 / DNA損傷 / マウス / 循環器、高血圧 |
|---|
| Research Abstract |
It is unknown that accumulation of oxidative DNA damage can accelerates atherosclerosis. We used Apoe^<-/-> mice overexpressing human MTH1 which catalyses 8-oxoGTP. The severity of atherosclerosis of hMTH1-Tg/Apoe^<-/-> mice was not different from Apoe-i- mice.
|
Report
(3 results)
Research Products
(8 results)
