Oxidative DNA damage and its defense mechanism in atherosclerosis

• Project/Area Number: 20790535
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyushu University
• Principal Investigator: 鳥巣 久美子 Kyushu University, 生体防御医学研究所, (非常勤研究員) (20448434)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 分子血管病態学 / 動脈硬化 / DNA損傷 / マウス / 循環器、高血圧

Research Abstract

It is unknown that accumulation of oxidative DNA damage can accelerates atherosclerosis. We used Apoe^<-/-> mice overexpressing human MTH1 which catalyses 8-oxoGTP. The severity of atherosclerosis of hMTH1-Tg/Apoe^<-/-> mice was not different from Apoe-i- mice.

Research Products

• [Presentation] 脳梗塞感受性遺伝子Prkchの欠損はApoe遺伝子欠損マウスにおける高脂血症と動脈硬化を改善する (2010)
  • Author(s): 鳥巣久美子、張学礼、野中麻里、中別府雄作
  • Organizer: 第2回Kyushu CVD Conference
  • Place of Presentation: 福岡
  • Year and Date: 2010-01-23
• [Presentation] Disruption of Prkch gene for protein kinase C η efficiently attenuates atherosclerosis in mice (2009)
  • Author(s): 鳥巣久美子、張学礼、野中麻里、中別府雄作
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] 脳梗塞感受性遺伝子であるPRKCHは動脈硬化の進展に関与するか (2008)
  • Author(s): 鳥巣久美子、張学礼、中別府雄作
  • Organizer: 九州CVDカンファレンス第一回研究会
  • Place of Presentation: 福岡
  • Year and Date: 2008-12-13
• [Presentation] 脳梗塞感受性遺伝子であるPRKCHは動脈硬化の進展に関与するか? (2008)
  • Author(s): 鳥巣久美子、張学礼、中別府雄作
  • Organizer: 九州CVDカンファレンス第一回研究会
  • Place of Presentation: 福岡
  • Year and Date: 2008-12-13
• [Presentation] Disruption of Prkch gene for protein kinse Cηefficiently attenuates atherosclerosis in mice. (2008)
  • Author(s): 鳥巣久美子、張学礼、野中麻里、中別府雄作
  • Organizer: 第32回分子生物学会年会
  • Year and Date: 2008-12-09
• [Remarks] ホームページ等
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• [Remarks]
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