The Role of NRSF in Heart Failure (Cardio-Adrenal Connection)

• Project/Area Number: 20790543
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Nara Medical University
• Principal Investigator: SATOSHI Somekawa Nara Medical University, 医学部・附属病院, 研究員 (90453167)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: NRSF / NRSE / アルドステロン / 副腎 / 心不全 / 転写抑制因子NRSF

Research Abstract

Transcriptional Repressor Neuron Restrictive Silencer Factor (NRSF) regulate aldosterone and cortisol/corticosteron synthesis by binding to NRSF-binding elements in CACNA1H gene in human and rat to indirectly induce CYP11B2 and CYP11B1 and by binding to those in human CYP11B2 and CYP11B1 genes to directly modify the expression of these genes.

Research Products

• [Journal Article] アルドステロン拮抗薬 (2010)
  • Author(s): 染川智、上村史朗、斎藤能彦
  • Journal Title: 綜合臨牀
• [Journal Article] Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor (2009)
  • Author(s): Somekawa S, Imagawa K, Naya N, Takemoto Y, Onoue K, Okayama S, Takeda Y, Kawata H, Horii M, Nakajima T, Uemura S Mochizuki N, Saito Y.
  • Journal Title: Endocrinology 150(7) Pages: 3110-3117
• [Journal Article] Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis (2009)
  • Author(s): Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Imagawa K, Nishida T, Morikawa Y, Takemoto Y, Asai O, Soeda T, Okayama S, Ishigami K, Nakatani K, Kawata H, Horii M, NakajimaT, Altai Y, Iwano M, Saito Y.
  • Journal Title: Circulation 120(24) Pages: 2470-2477
• [Journal Article] Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis (2009)
  • Author(s): Takemoto Y, Kawata H, Soeda T, Imagawa K, Somekawa S, Takeda Y, Uemura S, Matsumoto M, Fujimura Y, Jo J, Kimura Y, Tabata Y, Saito Y.
  • Journal Title: Arterioscler Thromb Vase Biol. 29(6) Pages: 857-862
• [Journal Article] Usefulness of soluble Fms-like tyrosine kinase I as a biomarker of acute severe heart failure in patients with acute myocardial infarction (2009)
  • Author(s): Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Nishida T, Morikawa Y, Nakagawa H, Tsutsumi, T Sung JH, Takemoto Y, Soeda T, Okayama S, Ishigami K, Kawata H, Horii M, Nakajima T, Saito Y
  • Journal Title: Am J Cardiol (in press)
• [Journal Article] Treatment with recombinant placental growth factor (PIGF) enhances both angiogensis and arteriogenesis and improves survival after myocardial infarction (2009)
  • Author(s): Takeda Y, Uemura S, Iwama H, Imagawa K, Nishida T, Onoue K, Takemoto Y, Soeda T, Okayama S, Somekawa S, Ishigami K, Takaoka M, Kawata H, Kubo A, Horii M, Nakajima T, Saito Y
  • Journal Title: Circ. J 73(9) Pages: 1674-1682
• [Journal Article] Long term follow-up of neointimal coverage of sirolimus-eluting stouts: Evaluation with optical coherencetomography (2009)
  • Author(s): Ishigami K, Uemura S, Morikawa Y, Soeda T, Okayama S, Nishida T, Takemoto Y, Onoue K, Somekawa S, Takeda Y, Kawata H, Horii M Saito Y
  • Journal Title: Circ J (in press)
• [Journal Article] Morphological features of coronary arteries in patients with coronary spastic angina: Assessment with intracoronary optical coherence tomography (2009)
  • Author(s): Morikawa Y, Uemura S, Ishigami K, Soeda T, Okayama S, Takemoto Y, Onoue K, Somekawa S, Nishida T, Takeda Y, Kawata H, Horii M Saito Y
  • Journal Title: Int J Cardiol (in press)
• [Journal Article] Novel application of black-blood echo-planar imaging to the assessment of myocardial infarction (2009)
  • Author(s): Okayama S, Uemura S, Watanabe M, Morikawa Y, Onoue K, Soeda T, Iwama H, Somekawa S, Takeda Y, Uramoto H, Kobayashi Y, Saito Y
  • Journal Title: Heart and Vessel (in press)
• [Journal Article] Non-contrast MRI for the evaluation of hydronephrotic and dysfunctioning kidney secondary to testicular cancer (2009)
  • Author(s): Okayama 5, Matsui M, Somekawa S, Iwano M, Saito Y.
  • Journal Title: lien Fail 31(2) Pages: 153-158
• [Journal Article] Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor (2009)
  • Author(s): Somekawa S
  • Journal Title: Endocrinology 150 Pages: 3110-3117
  • Peer Reviewed
• [Journal Article] Progression of non-culprit coronary artery atherosclerosis after acute myocardial infarction in comparison with stable angina pectoris (2008)
  • Author(s): Okayama S, Uemura S, Nishida T, Morikawa Y, Onoue K, Takemoto Y, Soeda T, Somekawa S, Ishigami K, Takeda Y, Horii M, Kawata H, Takaoka M, Nakajima T, Saito Y.
  • Journal Title: J. Atheroscler. Thromb 15(5) Pages: 228-234
• [Journal Article] The specific mineralocorticoid receptor blocker eplerenone attenuates left ventricular remodeling in mice lacking the gene encoding guanylyl cyclase-A (2008)
  • Author(s): Zhang Q, Saito Y, Naya N, Imagawa K, Somekawa S, Kawata H, Takeda Y, Uemura S, Kishimoto I, Nakao K.
  • Journal Title: Hypertens. Res. 31(6) Pages: 1251-1256
• [Journal Article] The Specific Mineralocorticoid Receptor Blocker Eplerenone Attenuates Left Ventricular Remodeling in Mice Lacking the Gene Encoding Guanylyl Cyclase-A (2008)
  • Author(s): Q Zhang, Saito Y, Naya N, Imagawa K, Somekawa S, Kawata H, Takeda Y, Uemura S, et.al.
  • Journal Title: Hypertension Research 31 Pages: 1251-1256
  • Peer Reviewed
• [Presentation] Guanylyl Cyclase-A Signaling Attenuates Salt Effect on Aldosterone -Induced Cardiac Remodeling (2009)
  • Author(s): Somekawa S
  • Organizer: Ainerican Heart Association Scientific Session 2009
  • Place of Presentation: オーランド(米国)
  • Year and Date: 2009-11-18
• [Presentation] Guanylyl Cyclase-A Signaling Attenuates Salt Effect on Aldosterone -Induced Cardiac Remodeling (2009)
  • Author(s): Somekawa S, Oingfen Mang. Nakagawa H, Sung J, Nishida T, Soeda T, Takemoto Y, Onoue K. Okayama S, Ishigami K, Kawata H, Horii M, Uemura S, Saito Y
  • Organizer: American Heart Association Scientific Session
• [Remarks]
  • URL: http://www.naramed-u.ac.jp/~lint/
• [Remarks]
  • URL: http://www.naramed-U.ac.jp/~lint/
• [Remarks]
  • URL: http://www.naramed-u.ac.jp/~1int/