The Role of NRSF in Heart Failure (Cardio-Adrenal Connection)
Project/Area Number |
20790543
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
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Research Institution | Nara Medical University |
Principal Investigator |
SATOSHI Somekawa Nara Medical University, 医学部・附属病院, 研究員 (90453167)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | NRSF / NRSE / アルドステロン / 副腎 / 心不全 / 転写抑制因子NRSF |
Research Abstract |
Transcriptional Repressor Neuron Restrictive Silencer Factor (NRSF) regulate aldosterone and cortisol/corticosteron synthesis by binding to NRSF-binding elements in CACNA1H gene in human and rat to indirectly induce CYP11B2 and CYP11B1 and by binding to those in human CYP11B2 and CYP11B1 genes to directly modify the expression of these genes.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor2009
Author(s)
Somekawa S, Imagawa K, Naya N, Takemoto Y, Onoue K, Okayama S, Takeda Y, Kawata H, Horii M, Nakajima T, Uemura S Mochizuki N, Saito Y.
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Journal Title
Endocrinology 150(7)
Pages: 3110-3117
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[Journal Article] Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis2009
Author(s)
Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Imagawa K, Nishida T, Morikawa Y, Takemoto Y, Asai O, Soeda T, Okayama S, Ishigami K, Nakatani K, Kawata H, Horii M, NakajimaT, Altai Y, Iwano M, Saito Y.
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Journal Title
Circulation 120(24)
Pages: 2470-2477
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[Journal Article] Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis2009
Author(s)
Takemoto Y, Kawata H, Soeda T, Imagawa K, Somekawa S, Takeda Y, Uemura S, Matsumoto M, Fujimura Y, Jo J, Kimura Y, Tabata Y, Saito Y.
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Journal Title
Arterioscler Thromb Vase Biol. 29(6)
Pages: 857-862
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[Journal Article] Usefulness of soluble Fms-like tyrosine kinase I as a biomarker of acute severe heart failure in patients with acute myocardial infarction2009
Author(s)
Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Nishida T, Morikawa Y, Nakagawa H, Tsutsumi, T Sung JH, Takemoto Y, Soeda T, Okayama S, Ishigami K, Kawata H, Horii M, Nakajima T, Saito Y
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Journal Title
Related Report
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[Journal Article] Treatment with recombinant placental growth factor (PIGF) enhances both angiogensis and arteriogenesis and improves survival after myocardial infarction2009
Author(s)
Takeda Y, Uemura S, Iwama H, Imagawa K, Nishida T, Onoue K, Takemoto Y, Soeda T, Okayama S, Somekawa S, Ishigami K, Takaoka M, Kawata H, Kubo A, Horii M, Nakajima T, Saito Y
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Journal Title
Circ. J 73(9)
Pages: 1674-1682
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[Journal Article] Long term follow-up of neointimal coverage of sirolimus-eluting stouts: Evaluation with optical coherencetomography2009
Author(s)
Ishigami K, Uemura S, Morikawa Y, Soeda T, Okayama S, Nishida T, Takemoto Y, Onoue K, Somekawa S, Takeda Y, Kawata H, Horii M Saito Y
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Journal Title
Related Report
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[Journal Article] Morphological features of coronary arteries in patients with coronary spastic angina: Assessment with intracoronary optical coherence tomography2009
Author(s)
Morikawa Y, Uemura S, Ishigami K, Soeda T, Okayama S, Takemoto Y, Onoue K, Somekawa S, Nishida T, Takeda Y, Kawata H, Horii M Saito Y
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Journal Title
Related Report
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[Journal Article] Novel application of black-blood echo-planar imaging to the assessment of myocardial infarction2009
Author(s)
Okayama S, Uemura S, Watanabe M, Morikawa Y, Onoue K, Soeda T, Iwama H, Somekawa S, Takeda Y, Uramoto H, Kobayashi Y, Saito Y
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Journal Title
Heart and Vessel (in press)
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[Journal Article] Progression of non-culprit coronary artery atherosclerosis after acute myocardial infarction in comparison with stable angina pectoris2008
Author(s)
Okayama S, Uemura S, Nishida T, Morikawa Y, Onoue K, Takemoto Y, Soeda T, Somekawa S, Ishigami K, Takeda Y, Horii M, Kawata H, Takaoka M, Nakajima T, Saito Y.
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Journal Title
J. Atheroscler. Thromb 15(5)
Pages: 228-234
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[Presentation] Guanylyl Cyclase-A Signaling Attenuates Salt Effect on Aldosterone -Induced Cardiac Remodeling2009
Author(s)
Somekawa S, Oingfen Mang. Nakagawa H, Sung J, Nishida T, Soeda T, Takemoto Y, Onoue K. Okayama S, Ishigami K, Kawata H, Horii M, Uemura S, Saito Y
Organizer
American Heart Association Scientific Session
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