Clarification of the effect of inhalation of hydrogen gas for suppression of myocardial ischemia reperfusion injury.

• Project/Area Number: 20790544
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Keio University
• Principal Investigator: HAYASHIDA Kentaro Keio University, 医学部, 助教 (20383862)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 分子心臓病態学 / 虚血再還流障害 / 抗酸化作用 / 水素ガス / 虚血再潅流障害

Research Abstract

We tried to clarify precise mechanism for Clarifying molecular mechanisms of ischemia-reperfusion injury and considering about new method for administering hydrogen gas. Now we have started using animal model of ischemia reperfusion njury such as dog for dvaluating the effect of hydrogen gasand early clinical application of hydrogen gas. We are trying for early clinical application by further confirmation of safety.

Research Products

• [Journal Article] Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? (2009)
  • Author(s): Suzuki Y, Sano M, Hayashida K, Ohsawa I, Ohta S, Fukuda K.
  • Journal Title: FEBS Lett. 583(13) Pages: 2157-9
  • Peer Reviewed
• [Journal Article] Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis (2009)
  • Author(s): Tokudome S, Sano M, Shinmura K, Matsuhashi T, Morizane S, Moriyama H, Tamaki K, Hayashida K, Nakanishi H, Yoshikawa N, Shimizu N, Endo J, Katayama T, Murata M, Yuasa S, Kaneda R, Tomita K,Eguchi N, Urade Y, Asano K, Utsunomiya Y, Suzuki T, Taguchi R, Tanaka H, Fukuda K.
  • Journal Title: J Clin Invest 119(6) Pages: 1477-88
  • Peer Reviewed
• [Journal Article] Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? (2009)
  • Author(s): Suzuki Y, et al.
  • Journal Title: FEBS Lett 583 Pages: 2157-2159
  • Peer Reviewed
• [Journal Article] Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. (2009)
  • Author(s): Tokudome S, et al.
  • Journal Title: J Clin Invest. 119 Pages: 1477-1488
  • Peer Reviewed
• [Journal Article] Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury (2008)
  • Author(s): Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda K
  • Journal Title: Biochem Biophys Res Commun 373(1) Pages: 30-5
  • Peer Reviewed
• [Journal Article] Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion iniurv (2008)
  • Author(s): Hayashida K, et. al.
  • Journal Title: Biochem Biophys Res Commun 373 Pages: 30-35
  • Peer Reviewed
• [Presentation] Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury (2008)
  • Author(s): Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda K
  • Organizer: American Heart Association 2008 Keystone meeting
  • Place of Presentation: Keystone, Colorado
  • Year and Date: 2008-07-28
• [Presentation] Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury (2008)
  • Author(s): Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda K
  • Organizer: American College of Cardiology, 2008 Chicago
  • Place of Presentation: Ilinoi, YIA
  • Year and Date: 2008-03-30
• [Presentation] Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury (2008)
  • Author(s): Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda K
  • Organizer: The 72nd annual meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-03-28