| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Research Abstract |
Fatal arrhythmia such as ventricular tachycardia and ventricular fibrillation (VT/VF) occurs to a high rate for the condition of a patient with a myocardial infarction or heart failure. We examined the quantification of connexin 43 (Cx43) expressions by using the nuclear medicine techniques in the rabbit infarction model, and investigated the relation between the abnormal Cx43 distribution and the change of the norepinephrine metabolism of the sympathetic nerve ending (functional denervation) using 123I-metaiodobenzyleguanidine (MIBG) nuclear medicine. In the results of ^<123>I-anti-Cx43 in vitro ARG, the accumulation of Cx43 decreased at the infarction and neighboring areas which were corresponded to be confirmed by the Cx43 immunostaining, Azan stain, and MIBG exam. In addition the accumulation of Cx43 decreased in the interventricular septum. Because there were bundle of His and Purkinje fibers in the interventricular septum, and this mainstream gap junction was Cx40, therefore the decreased expressions of Cx43 might reflect the relative attenuation. The ^<123>I-anti-Cx43 in vitro ARG has a possibility to be effective for an identification of the diseased and physiological distribution of Cx43.
|
