The study of pathogenesis during respiratory tract infection usingCCL1 gene targeted mouse
| Project/Area Number |
20790563
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Yamagata University |
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Principal Investigator |
INOUE Sumito Yamagata University, 医学部, 助教 (70466621)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | CCL1 / COPD / 呼吸器感染症 |
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| Research Abstract |
We originally established novel gene targeted mice, which can strongly express theCCL1 only in the lung tissues under the control of surfactant protein C (SP-C) promoter. To date, we confirmed that significantly higher expression ofCCL1 in bronchial alveolar fluid (BALF) in CCL1 gene targeted mice, compared with control mice. To evaluate the role of CCL1 during the respiratory infection or pathogenesis of chronic obstructive pulmonary disease, bacterial infection or pulmonary emphysema will be induced in these mice.
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Report
(3 results)
Research Products
(14 results)
