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Lineage-specific survival signal of lung adenocarcinoma on the lung development master regulator

Research Project

Project/Area Number 20790566
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionNagoya University

Principal Investigator

YAMAGUCHI Tomoya  Nagoya University, 大学院・医学系研究科, 助教 (70452191)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肺腺癌 / リネジ特異的マスター調節因子 / リネジ特異的生存シグナル / 肺癌 / 癌化シグナル / 発癌 / 進展 / マスター調節因子
Research Abstract

Sustained TTF-1 expression plays a crucial role in the survival of lung adenocarcinoma, in addition to the development and maintenance of cell lineages in normal lung. In this study, we identified DOT-1, as a TTF-1-regulated gene, and we showed lung adenocarcinoma expressing DOT-1 are highly dependent on its expression for cell survival.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (2 results)

All 2008

All Patent(Industrial Property Rights) (2 results)

  • [Patent(Industrial Property Rights)] 細胞増殖阻害剤2008

    • Inventor(s)
      高橋隆山口知也冨田秀太
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Number
      2008-187857
    • Filing Date
      2008-07-18
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞増殖阻害剤2008

    • Inventor(s)
      高橋隆, 山口知也, 冨田秀太
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Number
      2008-187857
    • Filing Date
      2008-07-18
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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