| Project/Area Number |
20790570
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
ARIKAWA Tomohiro Kagawa University, 医学部, 助教 (70452670)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | Galectin-9 / myeloid-derived suppressor cells / T-cell mediated inflammation / Hersensitivity Pneumonitis / Meloid-derived suressor cell / Macrohae / Hypersensitivity Pneumonitis / Myeloid-derived suppressor cell / Macronhage |
|---|
| Research Abstract |
Gal-9 expands the monocytic myeloid-derived suppressor cells (MDSCs) which can suppress T-cell functions in the lesion during experimental hypersensitivity pneumonitis. As well-known that MDSCs can be subdivided into Ly-6C or Ly-6G positive cells, Gal-9 induced Ly-6C positive monocytic MDSCs both in vivo and in vitro. We thus conclude that Gal-9 may be an inducer of monocytic MDSCs in the presence of bacterial component(s).
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