Gal-9 expands immunosuppressive macrophages to ameliorate T-cell-mediated inflammation.

• Project/Area Number: 20790570
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Kagawa University
• Principal Investigator: ARIKAWA Tomohiro Kagawa University, 医学部, 助教 (70452670)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: Galectin-9 / myeloid-derived suppressor cells / T-cell mediated inflammation / Hersensitivity Pneumonitis / Meloid-derived suressor cell / Macrohae / Hypersensitivity Pneumonitis / Myeloid-derived suppressor cell / Macronhage

Research Abstract

Gal-9 expands the monocytic myeloid-derived suppressor cells (MDSCs) which can suppress T-cell functions in the lesion during experimental hypersensitivity pneumonitis. As well-known that MDSCs can be subdivided into Ly-6C or Ly-6G positive cells, Gal-9 induced Ly-6C positive monocytic MDSCs both in vivo and in vitro. We thus conclude that Gal-9 may be an inducer of monocytic MDSCs in the presence of bacterial component(s).

Research Products

• [Journal Article] Galectin-9 Attenuates Acute Lung Injury by Expanding CD14-Plasmacytoid Dendritic Cell-like Macrophages. (2011)
  • Author(s): Kojima Keisuke, et al.
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 184 Issue: 3 Pages: 328-339
  • Peer Reviewed
• [Journal Article] G alectin-9 expands immunosuppressive macrophages to ameliorate T cell-mediated lung inflammation. (2010)
  • Author(s): C Arikawa T, Saita N, Oomizu S, Ueno M, Matsukawa A, Katoh S, Kojima K, Nagahara K, Miyake M, Yamauchi A, Kohrogi H, Hirashima M
  • Journal Title: European Journal of Immunology 40(2) Pages: 548-558
  • Peer Reviewed
• [Journal Article] Galectin-9 expands immunosuppressive macrophages to ameliorate T cell-mediated lung inflammation (2010)
  • Author(s): Arikawa T, Saita N, Oomizu S, Ueno M, Matsukawa A, Katoh S, Kojima K, Nagahara K, Miyake M, Yamauchi A, Kohrogi H, Hirashima M.
  • Journal Title: European Journal of Immunology 40(2) Pages: 548-558
  • Peer Reviewed
• [Journal Article] G alectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages. (2009)
  • Author(s): Arikawa T, Watanabe K, Seki M, Matsukawa A, Oomizu S, Sakata K, Sakata A, Ueno M, Saita N, Niki T, Hirashima M
  • Journal Title: Clinical Immunology 133 Pages: 382-392
  • Peer Reviewed
• [Journal Article] Galectin-9 ameliorates immune complex-induced arthritis by regulating Fe gamma R expression on macrophages (2009)
  • Author(s): Arikawa T, Watanabe K, Seki M, Matsukawa A, Oomizu S, Sakata K, Sakata A, Ueno M, Saita N, Niki T, Hirashima M
  • Journal Title: Clinical Immunology 133 Pages: 382-392
  • Peer Reviewed
• [Presentation] Galectin-9 expands myeloid-derived suppressor cells in T cell-mediated lung inflammation、Tomohiro Arikawa (2009)
  • Author(s): Souichi Oomizu, Mitsuomi Hirashima
  • Organizer: 第8回四国免疫フォーラム
  • Place of Presentation: 香川
  • Year and Date: 2009-06-27
• [Presentation] Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages (2009)
  • Author(s): 有川智博, 渡邊浩大, 松川昭博, 大水総一, 仁木敏朗, 山内清明, 平島光臣
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] ガレクチン9で誘導される骨髄由来細胞による過敏性肺炎モデルの発症抑制 (2009)
  • Author(s): 税田直樹, 小嶋圭介, 興梠博次, 有川智博, 平島光臣
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
• [Presentation] Galectin-9誘導Gr-1+CD11b+F4/80+細胞のエンドトキシン誘導性肺損傷に対する抑制効果の検討 (2009)
  • Author(s): 小嶋圭介, 税田直樹, 津村真介, 田中麗苗, 有川智博, 塩田徹哉, 後藤英介, 平島光臣, 興梠博次
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
• [Presentation] Galectin-9 ameliorates immune complex-induced arthritis by regulating FcγR expression on macrophages (口頭発表) (2009)
  • Author(s): 有川智博、渡邊浩大、松川昭博、大水総一、仁木敏朗、山内清明、平島光臣
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: グランキューブ大阪
• [Presentation] Expansion of myeloid suppressor cells by galectin-9 ameliorates pulmonary hypersensitivity (2008)
  • Author(s): Tomohiro Arikawa(代表)
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2008-12-03
• [Presentation] Galectin-9 enhances anti-tumor immunity by increasing Tim-3 homotypic interactions between dendritic cells and CD8+ T cells (2008)
  • Author(s): Oomizu Souichi, Keiko Ngahara, Tomohiro Arikawa, et al.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] ガレクチン9は骨髄由来抑制性マクロファージ誘導によりT細胞による炎症を抑制する (2008)
  • Author(s): 有川智博, 他
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Book] 日本臨床,68(-)(通号 982)(増刊7)[2010.7]. 149～151 (2010)
  • Author(s): 平島光臣
  • Total Pages: 3
  • Publisher: 広範囲 血液尿化学検査, 免疫学的検査(第7版)4 ガレクチン-その数値をどう読むか
• [Book] ガレクチンをめぐって, Annual review呼吸器 (2009)
  • Author(s): 有川智博、谷口令奈、平島光臣
  • Publisher: 中外医学社
• [Book] Annual review呼吸器-ガレクチンをめぐって- (2009)
  • Author(s): 有川智博、谷口令奈、平島光臣
  • Publisher: 中外医学社
• [Book] Annual Review「呼吸器」 (2009)
  • Author(s): 有川智博(第一著者)
  • Publisher: 中外医学社