Development of Aspergillus biofilm model

• Project/Area Number: 20790572
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagasaki University
• Principal Investigator: IMAMURA Yoshifumi Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (90467960)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 呼吸器感染症 / アスペルギルス症 / 動物モデル / バイオフィルム / アスペルギルス / 慢性感染動物モデル

Research Abstract

Aspergillus is a pathogenic fungus, which cause severe chronic pulmonary infection to human. In this study, we showed that Aspergillus could form biofilm in vitro. By placing a biofilm formed plastic tube into the lungs, we could develop a chronic mouse model of pulmonary asperdillosis.

Research Products

• [Presentation] 慢性肺アスペルギルス症マウスモデル作成の試み (2009)
  • Author(s): 今村圭文、高園貴弘、泉川公一, 他
  • Organizer: 第3回アスペルギルス研究会
  • Place of Presentation: 千葉大学附属病院
  • Year and Date: 2009-09-26
• [Presentation] 慢性肺アスペルギルス症マウスモデル作成の試み (2009)
  • Author(s): 今村圭文, 他
  • Organizer: 第3回アスペルギルス研究会