| Project/Area Number |
20790574
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
ARIKI Shigeru Sapporo Medical University, 医学部, 助教 (80464478)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 呼吸器感染症 / 自然免疫 / 肺コレクチン / 細胞内寄生細菌 / 細胞内寄生菌 |
|---|
| Research Abstract |
Pulmonary collectins play important roles in innate immunity of the lung. In this study, we demonstrated that collectins prevent the spread of infection by inhibiting the growth of L. pneumophila and M. avium, and by agglutinating M. avium. Furthermore, collectins enhanced the clearance of L. pneumophila by macrophages.
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