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Loss-of Function screening for identification of new therapeutic target for malignant mesothelioma

Research Project

Project/Area Number 20790582
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

SUDO Hitomi  National Institute of Radiological Sciences, 分子イメージング研究センター, 准技術員 (10415416)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords中皮腫 / siRNA / 機能スクリーニング
Research Abstract

We conducted a large-scale functional screening of mesothelioma cells using a genome-wide small interfering RNA library. We determined that knockdown of 39 genes suppressed mesothelioma cell proliferation. In particular, COPA knockdown induced apoptosis and suppressed tumor growth in a mesothelioma mouse model. Therefore, COPA may have the potential of a therapeutic target of mesothelioma.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2010 2008

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Knockdown of COPA, Identified by Loss-of-Function Screen, Induces Apoptosis and Suppresses Tumor Growth in Mesothelioma Mouse Mode2010

    • Author(s)
      Hitomi Sudo, Atsushi B. Tsuji, Aya Sugyo, Masakazu Kohda, Chizuru Sogawa, Chisato Yoshida, Yoshi-nobu Harada, Okio Hino Tsuneo Saga
    • Journal Title

      Genomics 95

      Pages: 210-216

    • Related Report
      2010 Final Research Report
  • [Journal Article] Knockdown of COPA, Identified by Loss-of-Function Screen, Induces Apoptosis and Suppresses Tumor Growth in Mesothelioma Mouse Model2010

    • Author(s)
      Hitomi Sudo
    • Journal Title

      Genomics 95

      Pages: 210-216

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 中皮腫に対する治療薬のターゲット遺伝子のスクリーニング2008

    • Author(s)
      須藤仁美、辻厚至、須堯綾、曽川千鶴、吉田千里、樋野興夫、佐賀恒夫
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 中皮腫の増殖に関わる遺伝子の大規模スクリーニング2008

    • Author(s)
      須藤仁美、辻厚至、曽川千鶴、原田良信、樋野興夫、佐賀恒夫
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2010 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2018-01-24  

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