Podocyte-protective effects of vitamin D

• Project/Area Number: 20790593
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Osaka University
• Principal Investigator: MATSUI Isao Osaka University, 医学系研究科, 助教 (60456986)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 糸球体上皮細胞 / vitamin D / 慢性腎臓病 / vitamin D recetor / レニン / vitamin D receptor

Research Abstract

We have proved that active vitamin D and its analogue 22-oxacalcitriol protect podocytes from injury in puromycin aminonucleoside induced nephrosis rats. Because podocyte injuries and resultant proteinuria are major risk factors in chronic kidney disease (CKD), our finding provides new therapeutic strategy for the prevention of CKD.

Research Products

• [Journal Article] ビタミンDの腎保護作用 (2010)
  • Author(s): 松井功
  • Journal Title: 医学のあゆみ 233巻3号 Pages: 256-256
• [Journal Article] Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats (2009)
  • Author(s): Isao Matsui, Takayuki Hamano, Kodo Tomida, Kazunori Inoue, Yoshitsugu Takabatake, Yasuyuki Nagasawa, Noritaka Kawada, Takahito Ito, Hiroshi Kawachi, Hiromi Rakugi, Enyu Imai, Yoshitaka Isaka
  • Journal Title: Nephrol Dial Transplant 24(8) Pages: 2354-61
  • Peer Reviewed
• [Journal Article] Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats. (2009)
  • Author(s): Isao Matsui, et al.
  • Journal Title: Nephrology Dialysis Transplantation 24 Pages: 2354-2361
  • Peer Reviewed
• [Journal Article] Vitamin Dの腎保護作用
  • Author(s): 松井攻
  • Journal Title: 医学のあゆみ (in press)
• [Journal Article] Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats
  • Author(s): Isao Matsui, et.al.
  • Journal Title: Nephrology Dialysis Transplantation (in press)
  • Peer Reviewed
• [Presentation] Maxacalcitol ameliorates kidney injury in Dahl salt-sensitive rats in a rennin-independent manner (2010)
  • Author(s): Kazunori Inoue, Isao Matsui, Chikako Nakano, Yoshitaka Isaka, Hiromi Rakugi
  • Organizer: ISN NEXUS
  • Place of Presentation: Kyoto
  • Year and Date: 2010-04-16
• [Presentation] Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside -induced nephrosis in rats (2009)
  • Author(s): Isao Matsui
  • Organizer: ROD-21研究会
  • Place of Presentation: 船橋
  • Year and Date: 2009-09-05
• [Presentation] Vitamin Dの腎保護作用 (2009)
  • Author(s): 松井功
  • Organizer: ROD 21研究会
  • Place of Presentation: クロスウェーブ船橋
  • Year and Date: 2009-09-05
• [Presentation] Vitamin Dはネフローゼラットの尿蛋白を減少させる (2008)
  • Author(s): 松井功, ら
  • Organizer: 第51回日本腎臓学会学術総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-06-01
• [Presentation] ビタミンDはネフローゼラソトの尿蛋白を減少させる (2008)
  • Author(s): 松井功、濱野高行、三上聡司、冨田弘道、田中啓隆、猪阪善隆、伊藤孝仁、今井圓裕、楽木宏実
  • Organizer: 日本腎臓学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-31
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/kid/basicresearch.html
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/kid/basicresearch.html