Podocyte-protective effects of vitamin D
| Project/Area Number |
20790593
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUI Isao Osaka University, 医学系研究科, 助教 (60456986)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 糸球体上皮細胞 / vitamin D / 慢性腎臓病 / vitamin D recetor / レニン / vitamin D receptor |
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| Research Abstract |
We have proved that active vitamin D and its analogue 22-oxacalcitriol protect podocytes from injury in puromycin aminonucleoside induced nephrosis rats. Because podocyte injuries and resultant proteinuria are major risk factors in chronic kidney disease (CKD), our finding provides new therapeutic strategy for the prevention of CKD.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats2009
Author(s)
Isao Matsui, Takayuki Hamano, Kodo Tomida, Kazunori Inoue, Yoshitsugu Takabatake, Yasuyuki Nagasawa, Noritaka Kawada, Takahito Ito, Hiroshi Kawachi, Hiromi Rakugi, Enyu Imai, Yoshitaka Isaka
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Journal Title
Nephrol Dial Transplant 24(8)
Pages: 2354-61
Related Report
Peer Reviewed
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