The novel mechanism of the phosphate transporter Npt2a dependent regulation of vitamin D homeostasis in kidney
| Project/Area Number |
20790594
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YAMAMOTO Hironori The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (60314861)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 水 / 電解質代謝学 / 転写解析 / ビタミンD合成酵素 / 甲状腺ホルモン / リン酸輸送担体 / クロマチン修飾 / 腎臓 / ビタミンD / 代謝酵素 / トランスポーター / 転写因子 / 遺伝子発現 |
|---|
| Research Abstract |
In this study, we analyzed the molecular mechanism of new regulation of vitamin D metabolism by thyroid hormone 13 in kidney. We demonstrated that thyroid hormone receptor betal and VDIR is important factor for the T3-dependent repression of the vitamin D synthesis enzyme Cyp27b1 gene. And, we found that the neither VDR nor Klotho was essential to the Cyp27bl gene control by T3, furthermore, we demonstrated that the phosphate transporter Npt2a gene play a critical role for the T3-dependent renal Cyp27bl gene repression using the Npt2a deficient mice.
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Report
(3 results)
Research Products
(51 results)
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[Journal Article] Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gone2010
Author(s)
Ishiguro M, Yamamoto H, Masuda Kozai M, Takei Y, Tanaka S, Sato T, Segawa H, Taketani Y, Arai H, Miyamoto K, Takeda E
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Journal Title
Biochem J 427(1)
Pages: 161-9
Related Report
Peer Reviewed
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[Journal Article] Dietary phosphorus acutely impairs endothelial function2009
Author(s)
Shuto F, Taketani Y, Tanaka R, Harada N, Isshiki M, Sate M, Nashiki K, Amo K, Yamamoto H, Higashi Y, Nakaya Y, Takeda E
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Journal Title
J Am Soc Nephrol 20(7)
Pages: 1504-12
Related Report
Peer Reviewed
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