The role of osteopontin in aldosterone-induced renal fibrosis
Project/Area Number |
20790595
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Kidney internal medicine
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Research Institution | Ehime University |
Principal Investigator |
IRITA Jun Ehime University, 医学部・附属病院, 医員 (00423442)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | オステオポンチン / アルドステロン / 腎線維化 / 酸化ストレス / 炎症 / オステオポンチンノックアウト |
Research Abstract |
Osteopontin (OPN) has been implicated in the pathology of several renal conditions. The aim of the present study was to clarify the roles of OPN in aldosterone-mediated renal injury by infusing aldosterone into either wild type (WT) or OPN knockout mice (OPN^<-/->). We used uninephrectomized mice treated with aldosterone and high salt to exaggerate renal fibrosis. These results indicate OPN is a promoter of aldosterone-induced inflammation, oxidative stress and interstitial fibrosis in the kidney and suggest that inhibition of OPN may be a potential therapeutic target for prevention of renal injury.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Renal resistance index is a marker of future renal dysfunction in patients with essential hypertension.2010
Author(s)
Okura T, Kurata M, Irita J, Enomoto D, Jotoku M, Nagao T, Koresawa M, Kojima S, Hamano Y, Mashiba S, Miyoshi K, Higaki J.
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Journal Title
J Nephrol. 23
Pages: 175-80
Related Report
Peer Reviewed
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