The role of osteopontin in aldosterone-induced renal fibrosis

• Project/Area Number: 20790595
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Ehime University
• Principal Investigator: IRITA Jun Ehime University, 医学部・附属病院, 医員 (00423442)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: オステオポンチン / アルドステロン / 腎線維化 / 酸化ストレス / 炎症 / オステオポンチンノックアウト

Research Abstract

Osteopontin (OPN) has been implicated in the pathology of several renal conditions. The aim of the present study was to clarify the roles of OPN in aldosterone-mediated renal injury by infusing aldosterone into either wild type (WT) or OPN knockout mice (OPN^<-/->). We used uninephrectomized mice treated with aldosterone and high salt to exaggerate renal fibrosis. These results indicate OPN is a promoter of aldosterone-induced inflammation, oxidative stress and interstitial fibrosis in the kidney and suggest that inhibition of OPN may be a potential therapeutic target for prevention of renal injury.

Research Products

• [Journal Article] Undercarboxylated Osteocalcin Is a Biomarker of Carotid Calcification in Patients with Essential Hypertension. (2010)
  • Author(s): Okura T, Kurata M, Enomoto D, Jotoku M, Nagao T, Desilva VR, Irita J, Miyoshi KI, Higaki J.
  • Journal Title: Kidney Blood Press Res. 33 Pages: 66-71
  • Peer Reviewed
• [Journal Article] Renal resistance index is a marker of future renal dysfunction in patients with essential hypertension. (2010)
  • Author(s): Okura T, Kurata M, Irita J, Enomoto D, Jotoku M, Nagao T, Koresawa M, Kojima S, Hamano Y, Mashiba S, Miyoshi K, Higaki J.
  • Journal Title: J Nephrol. 23 Pages: 175-80
  • Peer Reviewed
• [Journal Article] Elevated serum uric acid is an independent predictor for cardiovascular events in patients with severe coronary artery stenosis: subanalysis of the Japanese Coronary Artery Disease (JCAD) Study. (2009)
  • Author(s): Okura T, Higaki J, Kurata M, Irita J, Miyoshi K, Yamazaki T, Hayashi D, Kohro T, Nagai R.
  • Journal Title: Circ J. 73 Pages: 885-91
  • NAID: 10025930303
  • Peer Reviewed
• [Journal Article] Osteopontin in rat renal fibroblasts: functional properties and transcriptional regulation by aldosterone. (2008)
  • Author(s): Irita J, Okura T, Kurata M, Miyoshi K, Fukuoka T, Higaki J.
  • Journal Title: Hypertension. 51 Pages: 507-13
  • Peer Reviewed
• [Presentation] レニン・アンジオテンシン・アルドステロン系とオステオポンチンとの関連 (2010)
  • Author(s): 入田純, 大蔵隆文, 檜垣實男
  • Organizer: 第39回日本心脈管作動物質学会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-02-05
• [Presentation] アルドステロン誘導腎障害におけるオステオポンチンの役割-OPN KOマウスを用いた検討. (2010)
  • Author(s): 入田純
  • Organizer: 第39回日本心脈管作動物質学会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-02-05
• [Presentation] アルドステロンによる腎線維化には、オステオポンチンにより惹起される酸化ストレスが関与する (2009)
  • Author(s): 入田純, 大蔵隆文, 他6名
  • Organizer: 第32回日本高血圧学会総会
  • Place of Presentation: 大津
• [Presentation] Osteopontin deficiency protects against aldosterone-induced inflammation, oxidative stress and interstitial fibrosis in the kidney (2009)
  • Author(s): Irita J, Okura T, et al, (他6名)
  • Organizer: 63rd High Blood Pressure Research Conference 2009
  • Place of Presentation: Chicago, IL, USA.
• [Presentation] アルドステロン誘導腎障害におけるオステオポンチンの役割-OPN KOマウスを用いた検討 (2009)
  • Author(s): 入田純, 大蔵隆文, 他6名
  • Organizer: 第59回日本腎蔵学会学術集会
  • Place of Presentation: 横浜
• [Presentation] アルドステロン誘導腎障害におけるオステオポンチンの役割-OPN KOマウスを用いた検討. (2009)
  • Author(s): 入田純
  • Organizer: 第59回日本腎臓学会学術集会
  • Place of Presentation: 横浜
• [Presentation] アルドステロン誘導腎障害におけるオステオポンチンの役割-OPN KOマウスを用いた検討. (2009)
  • Author(s): 入田純
  • Organizer: 63^<rd> High Blood Pressure Reseach Confbrence
  • Place of Presentation: アメリカ合衆国シカゴ
• [Presentation] アルドステロン誘導腎障害におけるオステオポンチンの役割-OPN KOマウスを用いた検討. (2009)
  • Author(s): 入田純
  • Organizer: 第32回日本高血圧学会総会
  • Place of Presentation: 大津