| Project/Area Number |
20790596
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
KOBAYASHI Chiyoko Kumamoto University, 発生医学研究所, 助教 (20342785)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 腎臓学 / 腎臓発生 / 前駆細胞 / 発生・再生 / 腎臓 |
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| Research Abstract |
The metanephros is the main filtrating organ of the mammalian organism. The basic structural and functional unit of the kidney is the nephron, which performs a multitude of tasks including blood filtration, re-absorption of salt, water and other compounds. These functions can be related to specific ‘units' in each nephron that are formed in a tightly controlled manner during development. Induction of the kidney occurs through reciprocal interactions between the ureteric bud and the metanephric mesenchyme. The mesenchymal cell sequentially form condensates, renal vesicles, comma- and S-shaped bodies, and terminal epithelia of glomeuli, proximal and distal tubules. To generate multiple cell lineages for kidney regeneration, there exist three obstacles to be overcome; (1) derivation of the renal progenitors; (2) expansion of the renal progenitors; and (3) control of lineage commitment of the renal progenitors toward differentiated cell types. The recent work on iPS formation suggests that a specific combination of multiple factors might be the most effective way to reprogram the cells. To develop of gene transducing methods into the kidney, we first tested lentivirus vector system.
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