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Clarification of urate transporter molecular complex and dynamic regulation in the kidney.

Research Project

Project/Area Number 20790597
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionKyorin University

Principal Investigator

FUKUTOMI Toshiyuki  Kyorin University, 医学部, 助教 (30439187)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsトランスポーター / 尿酸 / PDZタンパク質 / タンパク質間相互作用 / URAT1 / PDZK1 / 腎臓 / リン酸化 / 高尿酸血症
Research Abstract

Renal urate transport system plays an important role in the regulation of plasma urate level. URAT1 is one of the major urate transporters in the kidney. Therefore, this study focused on elucidating URAT1-interacting protein(s) and their dynamic regulation through phosphorylation. URAT1 was shown to be bound to an organic anion transporter, OAT4, via a scaffold protein, PDZK1. In addition, increased transport activity was observed when each transporter interacted with PDZK1. Together with the fact that a phosphomimetic mutation in the URAT1 binding site of PDZK1 abolished the URAT1-PDZK1 interaction suggest a novel regulation mechanism for a URAT1 containing "urate transportsome".

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Book (2 results)

  • [Journal Article] 特集「アンモニア代謝と酸塩基調節」近位尿細管のグルタミン輸送とアンモニア代謝2009

    • Author(s)
      安西尚彦、福冨俊之、櫻井裕之
    • Journal Title

      腎と透析 67

      Pages: 39-43

    • Related Report
      2009 Final Research Report
  • [Journal Article] 特集「アンモニア代謝と酸塩基調節」近位尿細管のグルタミン輸送とアンモニア代謝2009

    • Author(s)
      安西尚彦
    • Journal Title

      腎と透析 67

      Pages: 39-43

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Interactions of human organic anion transporters with aristolochic acids

    • Author(s)
      Babu E., Takeda M., Nishida R., Noshiro-Kofuji R., Yoshida M., Ueda S., Fukutomi T., Anzai N., Endou H.
    • Journal Title

      JPS (in press)

    • NAID

      10027745688

    • Related Report
      2009 Final Research Report
  • [Journal Article] Interactions of human organic anion transporters with aristolochic acids

    • Author(s)
      Ellappan Babu
    • Journal Title

      J Pharmacol Sci (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 尿酸輸送機構の解明を目的とした尿酸トランスポーター過剰発現マウスの解析2010

    • Author(s)
      木村徹、塚田愛、Sirirat Amonpatumrat、福冨俊之、Promsuk Jutabha、市田公美河原克雅、金井好克、安西尚彦、櫻井裕之
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] ( 1北海道大・薬, 2Georgia医科大)(ポスター):PDZK1 is a binding partner of sodium - coupled monocarboxylate transporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in human kidney2009

    • Author(s)
      Sunena Srivastava, Naohiko Anzai, Seiji Miyauchi1, Daisaku Miura, Toru Kimura, Toshiyuki Fukutomi, Vadivel Ganapathy2, Hiroyuki Sakurai
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      京都
    • Year and Date
      2009-07-31
    • Related Report
      2009 Final Research Report
  • [Presentation] (ポスター) URAT1セミノックインマウスを用いた尿酸代謝機構の解析2009

    • Author(s)
      塚田愛、木村徹、福冨俊之、Promsuk Jutabha、金井好克、市田公美、安西尚彦、櫻井裕之
    • Organizer
      第4回トランスポーター研究会年会
    • Place of Presentation
      文京区
    • Year and Date
      2009-05-23
    • Related Report
      2009 Final Research Report
  • [Presentation] 尿酸トランスポーターURAT1とPDZドメインタンパク質PDZK1との相互作用のリン酸化による動的制御の可能性2008

    • Author(s)
      福冨俊之、安西尚彦、木村徹、櫻井裕之
    • Organizer
      トランスポーターワークショップin鶴岡
    • Place of Presentation
      山形
    • Year and Date
      2008-11-15
    • Related Report
      2009 Final Research Report
  • [Presentation] 尿酸トランスポーターURAT1とPDZドメインタンパク質PDZK1との相互作用のリン酸化による動的制御の可能性2008

    • Author(s)
      福冨俊之
    • Organizer
      トランスポーターワークショップIN鶴岡
    • Place of Presentation
      東北公益大ホール(山形県鶴岡市)
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Book] 薬物トランスポーター(第1章8)27. SLC22A12(URAT1))2009

    • Author(s)
      安西尚彦、福冨俊之
    • Publisher
      最新ライブラリー株式会社羊土社
    • Related Report
      2009 Final Research Report
  • [Book] 薬物トランスポーター最新ライブラリー2009

    • Author(s)
      安西尚彦
    • Publisher
      株式会社羊土社
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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