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A basic study for Application to treatment of the refractory glomerulonephritis using CD26

Research Project

Project/Area Number 20790600
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionJikei University School of Medicine

Principal Investigator

KOBAYASHI Seiji  Jikei University School of Medicine, 医学部, 助教 (80408400)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsCD26 / 難治性糸球体腎炎 / lipid rafts / T細胞
Research Abstract

CD26 has an important role in T-cell activation and is costimulatory molecule. We demonstrated that the expression level of lipid rafts to the peripheral blood T cell surface increased over time by costimulation of CD3 and CD26. Moreover, anti CD26 antibody treatment of peripheral blood T cells led to increased surface expression of Lipid rafts. On the other hand, after costimulation under the immunosuppressive drugs treatment, the expression of lipid rafts on T cells decreases drugs concentration-dependently and over time with T-cell proliferation being inhibited. Our results suggest that lipid rafts may become the biomarker when we evaluate the effect of the immunosuppressive drug in patients with glomerulonephritis.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (1 results)

All 2009

All Presentation (1 results)

  • [Presentation] 経過中に急性溶連菌感染後糸球体腎炎(APSGN)を合併しネフローゼ症候群を呈したIgA腎症の一例2009

    • Author(s)
      小林政司、小池健太郎、鈴木孝秀、宮崎陽一、宇都宮保典、細谷龍男
    • Organizer
      日本腎臓学会東部学術大会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-02
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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