• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

the phosphorous regulatory mechanism of OPG knockout mouse

Research Project

Project/Area Number 20790601
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionJikei University School of Medicine

Principal Investigator

OHKIDO Ichiro  東京慈恵会医科大学, 医学部, 助教 (40372966)

Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
KeywordsOsteoprotegerin / FGF-23 / OPG / FGF23 / Klotho / 破骨細胞阻害因子 / Kltho / Osteorotegerin / Phosphate
Research Abstract

The phosphorus metabolic regulation is performed by the excretion from kidney, the absorption from intestinal tract, the exchange with bones, a balance of the transportation in the cell membrane. The main factor prescribing blood phosphorus concentrations is fixed by reabsorption by NaPi IIa of the lumen side of most proximal tubules by the phosphorus excretion from kidney. It is assumed that FGF-23 and OCIF : Osteoclast inhibitory factor/OPG : Osteoprotegerin) play the role that is important to clinical condition formation of the secondary hyperparathyroidism in the chronic renal failure. However, there are many any questions whether FGF-23 and OPG form PTH or 1α, 25(OH) 2D3 adjustment system and what kind of network. Therefore we determine molecular roles such as OPG in the chronic renal failure model mouse, FGF-23, klotho.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (35 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (24 results) (of which Peer Reviewed: 15 results) Presentation (8 results) Book (3 results)

  • [Journal Article] Guidelines and medication compliance2012

    • Author(s)
      Yokoyama K, Tanno Y, Ohkido I, Hosoya T
    • Journal Title

      Kidney Int

      Volume: 81(6) Pages: 595-595

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metanephros transplantation inhibits the progression of vascular calcification in rats with adenine-induced renal failure2012

    • Author(s)
      Yokote S, Yokoo T, Matsumoto K, Ohkido I, Utsunomiya Y, Kawamura T, et al.
    • Journal Title

      Nephron Exp Nephrol

      Volume: 120(1)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Difference in coronary artery intima and media calcification in autopsied patients with chronic kidney disease2011

    • Author(s)
      Yoshida H, Yokoyama K, Yaginuma T, Ohkido I, Yamamoto H, Utsunomiya Y, et al.
    • Journal Title

      Clin Nephrol

      Volume: 75(1) Pages: 1-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Difference in coronary artery intima and media calcification in autopsied patients with chronic kidney disease2011

    • Author(s)
      Yoshida H
    • Journal Title

      Clin Nephrol

      Volume: 75 Pages: 1-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Difference in coronary artery intima and media calcification in autopsied patients with chronic kidney disease.2011

    • Author(s)
      Yoshida H, Yokoyama K, Yaginuma T, Ohkido I, Yamamoto H, Utsunomiya Y, Kawakami M, Hosoya T.
    • Journal Title

      Clin Nephrol. 75(1)

      Pages: 1-7

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism : an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms2010

    • Author(s)
      Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T
    • Journal Title

      Nephron Clin Pract

      Volume: 115(4)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The hypothesis that bone turnover influences FGF23 secretion2010

    • Author(s)
      Ohkido I, Yokoyama K, Kagami S, Hosoya T
    • Journal Title

      Kidney Int

      Volume: 77(8) Pages: 743-743

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hosoya T Persistent alpha-Klotho(a-Kl) expression in the parathyroid glands of patients with secondary hyper-parathyroidism.2010

    • Author(s)
      Ohkido I, Yokoyama K, Imura A, Utsunomiya Y, Nabeshima Y.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 25(3) Pages: 1007-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyper-parathyroidism : an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms2010

    • Author(s)
      Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, et al.
    • Journal Title

      Nephron Clin Pract

      Volume: 115(4)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 注目の新薬シナカルセト塩酸塩(レグパラR)2010

    • Author(s)
      大城戸一郎, 横山啓太郎
    • Journal Title

      診断と治療

      Volume: 98(4) Pages: 685-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism : an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.2010

    • Author(s)
      Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T.
    • Journal Title

      Nephron Clin Pract. 115(4)

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] The hypothesis that bone turnover influences FGF23 secretion.2010

    • Author(s)
      Ohkido I, Yokoyama K, Kagami S, Hosoya T.
    • Journal Title

      Kidney Int. 77(8)

      Pages: 743-743

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Persistent alpha-Klotho (a-Kl) expression in the parathyroid glands of patients with secondary hyperparathyroidism.2010

    • Author(s)
      Ohkido I, Yokoyama K, Imura A, Utsunomiya Y, Hosoya T, Nabeshima Y.
    • Journal Title

      Nephrol Dial Transplant. 25(3)

      Pages: 1007-1008

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Persistent alpha-Klotho (a-K1) expression in the parathyroid glands of patients with secondary hyperparathyroidism.2010

    • Author(s)
      Ohkido I
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 25 Pages: 1007-1008

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The hypothesis that bone turnover influenced FGF23 secretion2010

    • Author(s)
      Ohkido I
    • Journal Title

      Kidney Int.

      Volume: 77 Pages: 743-745

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dihydropyridine-and voltage-sensitive Ca2+entry in human parathyroid cells2009

    • Author(s)
      Yokoyama K, Matsuba D, Adachi-Akahane S, Takeyama H, Tabei I, Suzuki A, Shibasaki T, Iida R, Ohkido I, Hosoya T, Suda N
    • Journal Title

      Exp Physiol

      Volume: 94(7) Pages: 847-55

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【リンコントロール基礎と実践】リン調節臓器腎とリン代謝2009

    • Author(s)
      大城戸一郎
    • Journal Title

      腎と骨代謝

      Volume: 22(4) Pages: 275-80

    • Related Report
      2011 Final Research Report
  • [Journal Article] Dihydropyridine- and voltage-sensitive Ca2+ entry in human parathyroid cells.2009

    • Author(s)
      Yokoyama K, Matsuba D, Adachi-Akahane S, Takeyama H, Tabei I, Suzuki A, Shibasaki T, Iida R, Ohkido I, Hosoya T, Suda N.
    • Journal Title

      Exp Physiol. 94(7)

      Pages: 847-855

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Dihydropyridine and voltage-sensitive Ca2+ entry in human parathyroid cells.2009

    • Author(s)
      Yokoyama K
    • Journal Title

      Exp Physiol. 94

      Pages: 847-855

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prescribing peritoneal dialysis in each patient with uremic toxins as the treatment marker.2009

    • Author(s)
      Yokoyama K
    • Journal Title

      Nephrol Dial Transplant. 24

      Pages: 3900-3901

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎とリン代謝2009

    • Author(s)
      大城戸一郎
    • Journal Title

      腎と骨代謝 22

      Pages: 275-280

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Osteoprotegerin affects the responsiveness of fibroblast growth factor-23 to high oral phosphate intake.2008

    • Author(s)
      Kagami S, Ohkido I, Yokoyama K, Shigematsu T, Hosoya T.
    • Journal Title

      Clin Nephrol. 70(4)

      Pages: 306-311

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Osteoprotegerin affects the responsiveness of fibroblast growth factor-23 to high oral phosphate intake2008

    • Author(s)
      Kagami S
    • Journal Title

      Clinical nephrology 70(4)

      Pages: 306-311

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集腎疾患の診療に役立つ新しい検査Osteoprotegerin2008

    • Author(s)
      大城戸一郎
    • Journal Title

      腎と透析 65(4)

      Pages: 545-548

    • Related Report
      2008 Annual Research Report
  • [Presentation] Sevelamer hydrochloride inhibits aortic calcification regardless of serum phosphorus concentrations2011

    • Author(s)
      Ohkido I, Yokoyama K, Hasegawa T, Hosoya T
    • Organizer
      American Society of Nephrology 44th Annual Renal Week Meeting
    • Place of Presentation
      Philadelphia
    • Year and Date
      2011-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Sevelamer hydrochloride inhibits aortic calcification regardless of serum phosphorus concentrations2011

    • Author(s)
      Ichiro Ohkido
    • Organizer
      ASN 44th Annual Renal Week Meeting
    • Place of Presentation
      Philadelphia
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血中Klotho蛋白の臨床的意義と今後の展望2011

    • Author(s)
      大城戸一郎, 横山啓太郎
    • Organizer
      第56回日本透析医学会学術集会・総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-07
    • Related Report
      2011 Final Research Report
  • [Presentation] シナカルセト塩酸塩による骨回転是正はFGF23動態へ影響を与える2010

    • Author(s)
      Yamamoto I, Yokoyama K, Ohkido I, et. Al
    • Organizer
      第55回日本透析医学会学術集会・総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 二次性副甲状腺機能亢進症患者における副甲状腺細胞でのalpha-Kl発現の検討2009

    • Author(s)
      大城戸一郎, 横山啓太郎, 鍋島陽一, 伊村明浩, 各務志野, 山本裕康, ほか
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 二次性副甲状腺機能亢進症患者における副甲状腺細胞でのalpha-K1発現の検討2009

    • Author(s)
      大城戸一郎
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Alpha-Kl expressions remained in the parathyroid glands of patients with secondary hyperparathyroidism2008

    • Author(s)
      Ohkido I, Yokoyama K, Nabeshima YI, Imura H, Kagami S, et al.
    • Organizer
      American Society of Nephrology 41th Annual Renal Week Meeting
    • Place of Presentation
      San diego
    • Year and Date
      2008-11-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Vitamin D analogues with TGF- signal inhibition property ameliorates renal fibrotic lesions in UUO mice.

    • Author(s)
      Keitaro Yokoyama, Ichiro Ohkido, Ichiaki Ito, Akiko Murayama, Jun Yanagisawa, Tastuo Hosoya
    • Organizer
      2009 ASN 42th Annual Renal Week Meeting San diego
    • Related Report
      2010 Self-evaluation Report
  • [Book] 急性腎不全、慢性腎不全.豊島聡編集.疾病と病態生理2012

    • Author(s)
      大城戸一郎
    • Publisher
      南江堂
    • Related Report
      2011 Final Research Report
  • [Book] 腹膜透析療法マニュアル2011

    • Author(s)
      大城戸一郎
    • Publisher
      東京医学社
    • Related Report
      2011 Final Research Report
  • [Book] 尿細管障害.薬学生のための新臨床医学2009

    • Author(s)
      大城戸一郎
    • Publisher
      廣川書店
    • Related Report
      2011 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi