| Project/Area Number |
20790612
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
FUJIKAKE Nobuhiro National Center of Neurology and Psychiatry, 神経研究所 疾病研究第四部, 科研費研究員 (60467595)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 遺伝学 / 遺伝子 / 神経科学 / 脳神経疾患 / ショウジョウバエ / 神経変性疾患 / ポリグルタミン病 / スクリーニング / 神学経科 |
|---|
| Research Abstract |
The neurological phenotypes of the polyglutamine (polyQ) diseases have been reported to be caused by neuronal dysfunction rather than cell death. However, the mechanisms involved in polyQ-induced neuronal dysfunction in vivo are not fully understood. To investigate the mechanisms of polyQ-induced neuronal dysfunction in vivo, we screened for modifier genes of neuronal dysfunction using a Drosophila polyQ disease model. As a result, we successfully identified Sup1 and Sup5 genes as new genes that are involved in the mechanisms of polyQ-induced neuronal dysfunction.
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